UBD

Gene Symbol	UBD
Entrez Gene	10537
Alt Symbol	FAT10, GABBR1, UBD-3
Species	Human
Gene Type	protein-coding
Description	ubiquitin D
Other Description	diubiquitin|ubiquitin-like protein FAT10
Swissprots	O15205 Q5STL2 B0UZT6 Q96EC7 Q5SUK2
Accessions	CAA21458 EAX03201 O15205 AA878968 AF123050 AAD52982 AK311914 BAG34855 BC012472 AAH12472 CB111380 DB181897 DQ894624 ABM85550 Y12653 CAA73200 NM_006398 NP_006389
Function	Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization
Subcellular Location	Nucleus {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:19033385}. Cytoplasm {ECO:0000250}. Note=Accumulates in aggresomes under proteasome inhibition conditions.
Tissue Specificity	Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland. {ECO:0000269|PubMed:12730673, ECO:0000269|PubMed:9368598}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Poly-ubiquitin (linkage specific K48) full length protein - ab189737 from Abcam Category Protein Prices $452.00 Sizes 100 µg Source E. coli Species Human

Active human Poly-ubiquitin (linkage specific K63) full length protein - ab189749 from Abcam Category Protein Prices $342.00 Sizes 100 µg Source E. coli Species Human

Human Poly-ubiquitin (linkage specific K63) full length protein - ab189713 from Abcam Category Protein Source E. coli Species Human

Human Ubiquitin D full length protein - ab113594 from Abcam Category Protein Source E. coli Species Human

Human Ubiquitin D full length protein - ab190440 from Abcam Category Protein Source E. coli Species Human

FAT10 / UBD Antibody Blocking Peptide - LS-E913 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FAT10 / UBD Antibody Blocking Peptide - LS-E16836 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FAT10 Recombinant Protein - H00010537-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human FAT10 Protein - NBP1-72450 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

FAT10-Antibody-C-term-Blocking-peptide - BP11316b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human FAT10, CF - UL-900-250 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human His6-FAT10, CF - UL-910-250 from R&D Systems Category Protein Source E. coli-derived, Contains a 6-His tag

Recombinant Human FAT10 Rhodamine, CF - UL-914-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human FAT10 Agarose, CF - UL-920-500 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human FAT10 Biotin, CF - UL-912-050 from R&D Systems Category Protein Source E. coli-derived,

Human UBD protein - orb169501 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Source E. coli

Human UBD protein - orb246464 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

UBD protein (His tag) - 80R-1964 from Fitzgerald Category Protein Prices $270.00 Sizes 10 µg Source E.coli

Ubiquitin D Blocking Peptide - 33R-8192 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Ubiquitin D Protein - abx069592 from Abbexa Category Protein Source E.coli Species Human

Ubiquitin D (UBD) (1-165, His-tag) - AR39150PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

Ubiquitin D (UBD) (1-165, His-tag) - AR39150PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

Ubiquitin D (UBD) - H00010537-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Ubiquitin D (UBD) - H00010537-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UBD, 1-165aa, Human, His tag, E.coli - 01-P1208 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

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