DNMT3L

Gene Symbol DNMT3L
Entrez Gene 29947
Alt Symbol -
Species Human
Gene Type protein-coding
Description DNA (cytosine-5-)-methyltransferase 3-like
Other Description DNA (cytosine-5)-methyltransferase 3-like|cytosine-5-methyltransferase 3-like protein|human cytosine-5-methyltransferase 3-like protein
Swissprots Q9BUJ4 Q9UJW3 E9PB42
Accessions BAA95556 CBH19273 EAX09445 Q9UJW3 AF194032 AAF05812 BC002560 AAH02560 BQ028660 DQ892177 ABM83103 DQ895372 ABM86298 XM_011529536 XP_011527838 NM_013369 NP_037501 NM_175867 NP_787063
Function Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. {ECO:0000269|PubMed:17687327}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Expressed at low levels in several tissues including testis, ovary, and thymus.

Dnmt3L (A-4) - sc-393603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dnmt3L (A-4): sc-393603. Western blot analysis of Dnmt3L expression in non-transfected: sc-110760 (A) and human Dnmt3L transfected: sc-173143 (B) 293 whole cell lysates.

Dnmt3L (H-85) - sc-20705 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dnmt3L (H-85): sc-20705. Western blot analysis of Dnmt3L expression in mouse testis tissue extract (A) and ES-2 whole cell lysate (B).

Dnmt3L (N-14) - sc-10239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dnmt3L (N-14): sc-10239. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

Dnmt3L (P-15) - sc-10241 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Dnmt3L antibody - ab135753 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Dnmt3L antibody (ab135753) at 1/100 dilution + HeLa cell line lysate at 35 µg

Anti-Dnmt3L antibody - ab28968 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
Anti-Dnmt3L antibody (ab28968) at 1/500 dilution

Anti-Dnmt3L antibody - ab89412 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Dnmt3L antibody (ab89412) at 1 µg/ml + Human pancreas tissue lysate at 50 µg

Anti-Dnmt3L antibody - ab115522 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115522 at 10ug/ml staining Dnmt3L in Human tonsil tissue by immunohistochemistry (FFPE). Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Dnmt3L antibody - ab129688 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Dnmt3L antibody (ab129688) at 1/100 dilution + Jurkat cell line lysate at 35 µg

Anti-Dnmt3L antibody - ab17687 from Abcam

Host Chicken
Clonality Polyclonal

Anti-Dnmt3L antibody [S117-9] - ab93613 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody - LS-C332077 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cell using DNMT3L antibody.

Anti-DNMT3L Antibody (aa152-164) - LS-C6422 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DNMT3L Antibody (aa1-387) - LS-C128622 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DNMT3L Antibody (aa152-164) - LS-C19023 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DNMT3L Antibody - Western Blot. Affinity Purified Rabbit anti-DNMT3L was used at a 1:1500 dilution to detect human DNMT3L by western blot after immunoprecipitation using the same antibody. Transfection of U2OS cells (10cm dish) was accomplished using 3 ug of GAL4-DNMT3L. Protein extraction using IPH at 150mM. For IP and WB conditions see Fuks et al. (2000). For western blotting the antibody was used at 0.4 ug/ml in TBS milk 2%, BSA 0.5%. Detection occurred using ECL. Note: this antibody works for western blotting only following immunoprecipitation. We have not had good success using the antibody directly for western blotting. The expected molecular weight of human DNMT3L is 43.6 kD.

Anti-DNMT3L Antibody (clone S117-9) - LS-C152959 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody (aa1-387, clone S117-9, Atto 390) - LS-C230938 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody (aa1-387, clone S117-9, Atto 488) - LS-C230940 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody (aa1-387, clone S117-9) - LS-C109036 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9
Western blot analysis of DNMT3L in a human tissue mix using a 1:1000 dilution of DNMT3L antibody.

Anti-DNMT3L Antibody (aa1-387, clone S117-9, Atto 594) - LS-C230941 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody (aa1-387, clone S117-9, Atto 633) - LS-C230943 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody (aa1-387, clone S117-9, Atto 680) - LS-C230944 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody (aa1-387, clone S117-9, Atto 655) - LS-C230945 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody (aa1-387, clone S117-9, Atto 700) - LS-C230946 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9

Anti-DNMT3L Antibody (aa1-387, clone S117-9, AP) - LS-C230947 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S117-9
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