| Gene Symbol |
DNMT3L
|
| Entrez Gene |
29947
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA (cytosine-5-)-methyltransferase 3-like
|
| Other Description |
DNA (cytosine-5)-methyltransferase 3-like|cytosine-5-methyltransferase 3-like protein|human cytosine-5-methyltransferase 3-like protein
|
| Swissprots |
Q9BUJ4 Q9UJW3 E9PB42
|
| Accessions |
BAA95556 CBH19273 EAX09445 Q9UJW3 AF194032 AAF05812 BC002560 AAH02560 BQ028660 DQ892177 ABM83103 DQ895372 ABM86298 XM_011529536 XP_011527838 NM_013369 NP_037501 NM_175867 NP_787063
|
| Function |
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. {ECO:0000269|PubMed:17687327}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed at low levels in several tissues including testis, ovary, and thymus.
|