MYLIP

Gene Symbol MYLIP
Entrez Gene 29116
Alt Symbol IDOL, MIR
Species Human
Gene Type protein-coding
Description myosin regulatory light chain interacting protein
Other Description E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor|E3 ubiquitin-protein ligase MYLIP|band 4.1 superfamily member BZF1|cellular modulator of immune recognition (c-MIR)|inducible degrader of the LDL-receptor|myosin regulatory light chain-interacting protein
Swissprots Q9BU73 Q9NRL9 Q8WY64 Q5TIA4 Q9UHE7
Accessions AAQ13409 EAW55366 EAW55367 Q8WY64 AF006003 AAQ13408 AF187016 AAF18974 AF212221 AAF87323 AF258586 AAG23789 AJ420601 AK026739 AK074391 AK314648 BAG37209 BC002860 AAH02860 BT007055 AAP35704 EU176184 ABW03635 HQ447323 ADQ31810 XM_005249032 XP_005249089 XM_005249033 XP_005249090 NM_013262 NP_037394
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:10593918, ECO:0000269|PubMed:12826659, ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:22109552}.
Subcellular Location Cytoplasm {ECO:0000305|PubMed:14550572}. Cell membrane {ECO:0000269|PubMed:14550572}; Peripheral membrane protein {ECO:0000269|PubMed:14550572}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10593918}.

MYLIP-Over-expression-Lysate - LY11592a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag MYLIP (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MYLIP gene

MYLIP overexpression lysate - LY415697 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

MYLIP 293 Cell Lysate - 407383 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

MYLIP Overexpression Lysate (Native) - NBL1-13432 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: MYLIP Overexpression Lysate (Adult Normal) [NBL1-13432] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MYLIP.

MYLIP Over-expression Lysate Product - GWB-AB26BE from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human MYLIP Knockdown Stable Cell Line - CSC-DC010010 from Creative biogene

Category Cell Line
Species Human
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