MYLIP

Gene Symbol	MYLIP
Entrez Gene	29116
Alt Symbol	IDOL, MIR
Species	Human
Gene Type	protein-coding
Description	myosin regulatory light chain interacting protein
Other Description	E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor|E3 ubiquitin-protein ligase MYLIP|band 4.1 superfamily member BZF1|cellular modulator of immune recognition (c-MIR)|inducible degrader of the LDL-receptor|myosin regulatory light chain-interacting protein
Swissprots	Q9BU73 Q9NRL9 Q8WY64 Q5TIA4 Q9UHE7
Accessions	AAQ13409 EAW55366 EAW55367 Q8WY64 AF006003 AAQ13408 AF187016 AAF18974 AF212221 AAF87323 AF258586 AAG23789 AJ420601 AK026739 AK074391 AK314648 BAG37209 BC002860 AAH02860 BT007055 AAP35704 EU176184 ABW03635 HQ447323 ADQ31810 XM_005249032 XP_005249089 XM_005249033 XP_005249090 NM_013262 NP_037394
Function	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:10593918, ECO:0000269|PubMed:12826659, ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:22109552}.
Subcellular Location	Cytoplasm {ECO:0000305|PubMed:14550572}. Cell membrane {ECO:0000269|PubMed:14550572}; Peripheral membrane protein {ECO:0000269|PubMed:14550572}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10593918}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MYLIP full length protein - ab153303 from Abcam Category Protein Source Wheat germ Species Human

Human MYLIP full length protein - ab198638 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

MYLIP / IDOL Blocking Peptide - LS-E7808 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MYLIP / IDOL Antibody Blocking Peptide - LS-E15882 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MYLIP Protein - H00029116-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MYLIP Blocking Peptide - NBP1-54903PEP from Novus Biologicals Category Peptide Prices $169.00 Sizes 100 µl Species Human

MYLIP-Antibody-Center-Blocking-peptide - BP5315c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MYLIP protein - orb244926 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human MYLIP protein - orb246183 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

MYLIP Blocking Peptide - 33R-1817 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MYLIP - H00029116-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MYLIP - H00029116-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MYLIP fusion protein - ag7720 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

MYLIP fusion protein - ag7273 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

IDOL Blocking Peptide - CBP4106 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Bovine, Monkey

Recombinant Human E3 ubiquitin-protein ligase MYLIP(MYLIP) - CSB-YP855506HU CSB-BP855506HU CSB-MP855506HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human E3 ubiquitin-protein ligase MYLIP(MYLIP) - CSB-EP855506HU from Cusabio Category Protein Source Yeast Species Human

MYLIP Protein - abx163398 from Abbexa Category Protein Species Human, Mouse, Rat

IDOL Blocking Peptide - abx162599 from Abbexa Category Peptide Species Human, Mouse, Bovine, Monkey

MYLIP-Antibody-Center-T126-Blocking-Peptide - BP7363c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MYLIP Peptide, Human - M34GP10010H from Creative Peptides Category Peptide Source Synthetic. Species Human

MYLIP Recombinant Protein (OPCA03059) - OPCA03059 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant Human E3 ubiquitin-protein ligase MYLIP - AP71485 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase MYLIP - AP73111 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Human

E3 ubiquitin-protein ligase MYLIP, Recombinant Protein - MBS9421349 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

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