MYLIP

Gene Symbol MYLIP
Entrez Gene 29116
Alt Symbol IDOL, MIR
Species Human
Gene Type protein-coding
Description myosin regulatory light chain interacting protein
Other Description E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor|E3 ubiquitin-protein ligase MYLIP|band 4.1 superfamily member BZF1|cellular modulator of immune recognition (c-MIR)|inducible degrader of the LDL-receptor|myosin regulatory light chain-interacting protein
Swissprots Q9BU73 Q9NRL9 Q8WY64 Q5TIA4 Q9UHE7
Accessions AAQ13409 EAW55366 EAW55367 Q8WY64 AF006003 AAQ13408 AF187016 AAF18974 AF212221 AAF87323 AF258586 AAG23789 AJ420601 AK026739 AK074391 AK314648 BAG37209 BC002860 AAH02860 BT007055 AAP35704 EU176184 ABW03635 HQ447323 ADQ31810 XM_005249032 XP_005249089 XM_005249033 XP_005249090 NM_013262 NP_037394
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:10593918, ECO:0000269|PubMed:12826659, ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:22109552}.
Subcellular Location Cytoplasm {ECO:0000305|PubMed:14550572}. Cell membrane {ECO:0000269|PubMed:14550572}; Peripheral membrane protein {ECO:0000269|PubMed:14550572}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:10593918}.

MYLIP CRISPR/Cas9 KO Plasmid (h) - sc-412034 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MYLIP HDR Plasmid (h) - sc-412034-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MYLIP Double Nickase Plasmid (h) - sc-412034-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MYLIP Double Nickase Plasmid (h2) - sc-412034-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MYLIP CRISPR Activation Plasmid (h) - sc-412034-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MYLIP CRISPR Activation Plasmid (h2) - sc-412034-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MYLIP Lentiviral Activation Particles (h) - sc-412034-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MYLIP Lentiviral Activation Particles (h2) - sc-412034-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MYLIP siRNA (h) - sc-95314 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MYLIP shRNA Plasmid (h) - sc-95314-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MYLIP shRNA (h) Lentiviral Particles - sc-95314-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MYLIP RNAi - H00029116-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU134691 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14838 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14838 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12688 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12688

MYLIP siRNA (Human) - CRH9205 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MYLIP (NM_013262.3) - SHH347988 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MYLIP(NM_013262.3) - SHH212123 from Creative biogene

Category siRNA
Species Reactivities Human

Human MYLIP siRNA - orb269707 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MYLIP shRNA Plasmid (Human) - CHH9205 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MYLIP miRNA 3'UTR clone - MiUTR1H-06581 from Creative biogene

Species Reactivities Human
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