| Gene Symbol |
MYLIP
|
| Entrez Gene |
29116
|
| Alt Symbol |
IDOL, MIR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myosin regulatory light chain interacting protein
|
| Other Description |
E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor|E3 ubiquitin-protein ligase MYLIP|band 4.1 superfamily member BZF1|cellular modulator of immune recognition (c-MIR)|inducible degrader of the LDL-receptor|myosin regulatory light chain-interacting protein
|
| Swissprots |
Q9BU73 Q9NRL9 Q8WY64 Q5TIA4 Q9UHE7
|
| Accessions |
AAQ13409 EAW55366 EAW55367 Q8WY64 AF006003 AAQ13408 AF187016 AAF18974 AF212221 AAF87323 AF258586 AAG23789 AJ420601 AK026739 AK074391 AK314648 BAG37209 BC002860 AAH02860 BT007055 AAP35704 EU176184 ABW03635 HQ447323 ADQ31810 XM_005249032 XP_005249089 XM_005249033 XP_005249090 NM_013262 NP_037394
|
| Function |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:10593918, ECO:0000269|PubMed:12826659, ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:22109552}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305|PubMed:14550572}. Cell membrane {ECO:0000269|PubMed:14550572}; Peripheral membrane protein {ECO:0000269|PubMed:14550572}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:10593918}.
|