| Gene Symbol |
DYRK3
|
| Entrez Gene |
8444
|
| Alt Symbol |
DYRK5, RED, REDK, hYAK3-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
|
| Other Description |
dual specificity tyrosine-phosphorylation-regulated kinase 3|dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5|protein kinase Dyrk3|regulatory erythroid kinase
|
| Swissprots |
Q7Z752 O43781 Q9HBY7 Q9HBY6 D3DT79
|
| Accessions |
EAW93533 EAW93534 EAW93535 O43781 AF186773 AAG17028 AF186774 AAG17029 AF327561 AAK16443 AK291189 BAF83878 AK308082 AK313245 BAG36056 AU126055 AY590695 AAT06103 BC015501 AAH15501 BC037269 AAH37269 JF432389 ADZ15606 Y12735 CAA73266 XM_005273315 XP_005273372 XM_005273316 XP_005273373 XM_006711576 XP_006711639 XM_011510060 XP_011508362 XM_011510061 XP_011508363 NM_001004023 NP_001004023 NM_003582 NP_003573
|
| Function |
Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling. {ECO:0000269|PubMed:10779429}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10779429}.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. {ECO:0000269|PubMed:10779429}.
|
