Gene Symbol | DYRK3 |
---|---|
Entrez Gene | 8444 |
Alt Symbol | DYRK5, RED, REDK, hYAK3-2 |
Species | Human |
Gene Type | protein-coding |
Description | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 |
Other Description | dual specificity tyrosine-phosphorylation-regulated kinase 3|dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5|protein kinase Dyrk3|regulatory erythroid kinase |
Swissprots | Q7Z752 O43781 Q9HBY7 Q9HBY6 D3DT79 |
Accessions | EAW93533 EAW93534 EAW93535 O43781 AF186773 AAG17028 AF186774 AAG17029 AF327561 AAK16443 AK291189 BAF83878 AK308082 AK313245 BAG36056 AU126055 AY590695 AAT06103 BC015501 AAH15501 BC037269 AAH37269 JF432389 ADZ15606 Y12735 CAA73266 XM_005273315 XP_005273372 XM_005273316 XP_005273373 XM_006711576 XP_006711639 XM_011510060 XP_011508362 XM_011510061 XP_011508363 NM_001004023 NP_001004023 NM_003582 NP_003573 |
Function | Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling. {ECO:0000269|PubMed:10779429}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10779429}. |
Tissue Specificity | Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. {ECO:0000269|PubMed:10779429}. |