Gene Symbol | DYRK3 |
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Entrez Gene | 8444 |
Alt Symbol | DYRK5, RED, REDK, hYAK3-2 |
Species | Human |
Gene Type | protein-coding |
Description | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 |
Other Description | dual specificity tyrosine-phosphorylation-regulated kinase 3|dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5|protein kinase Dyrk3|regulatory erythroid kinase |
Swissprots | Q7Z752 O43781 Q9HBY7 Q9HBY6 D3DT79 |
Accessions | EAW93533 EAW93534 EAW93535 O43781 AF186773 AAG17028 AF186774 AAG17029 AF327561 AAK16443 AK291189 BAF83878 AK308082 AK313245 BAG36056 AU126055 AY590695 AAT06103 BC015501 AAH15501 BC037269 AAH37269 JF432389 ADZ15606 Y12735 CAA73266 XM_005273315 XP_005273372 XM_005273316 XP_005273373 XM_006711576 XP_006711639 XM_011510060 XP_011508362 XM_011510061 XP_011508363 NM_001004023 NP_001004023 NM_003582 NP_003573 |
Function | Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling. {ECO:0000269|PubMed:10779429}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10779429}. |
Tissue Specificity | Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. {ECO:0000269|PubMed:10779429}. |
Dyrk3 CRISPR/Cas9 KO Plasmid (h) - sc-405124 from Santa Cruz Biotechnology
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Dyrk3 HDR Plasmid (h) - sc-405124-HDR from Santa Cruz Biotechnology
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Dyrk3 Double Nickase Plasmid (h) - sc-405124-NIC from Santa Cruz Biotechnology
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Dyrk3 Double Nickase Plasmid (h2) - sc-405124-NIC-2 from Santa Cruz Biotechnology
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Dyrk3 CRISPR Activation Plasmid (h) - sc-405124-ACT from Santa Cruz Biotechnology
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Dyrk3 CRISPR Activation Plasmid (h2) - sc-405124-ACT-2 from Santa Cruz Biotechnology
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Dyrk3 Lentiviral Activation Particles (h) - sc-405124-LAC from Santa Cruz Biotechnology
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Dyrk3 Lentiviral Activation Particles (h2) - sc-405124-LAC-2 from Santa Cruz Biotechnology
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Dyrk3 siRNA (h) - sc-39010 from Santa Cruz Biotechnology
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Dyrk3 shRNA Plasmid (h) - sc-39010-SH from Santa Cruz Biotechnology
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Dyrk3 shRNA (h) Lentiviral Particles - sc-39010-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU056791 from Sigma-Aldrich
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MISSION® siRNA - SIHK0650 from Sigma-Aldrich
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MISSION® siRNA - SIHK0649 from Sigma-Aldrich
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MISSION® siRNA - SIHK0648 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7596 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7596 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02390 from Sigma-Aldrich
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DYRK3 siRNA (Human) - CRH5532 from Cohesion Biosciences
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DYRK3 RNAi - H00008444-R03 from Novus Biologicals
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DYRK3 RNAi - H00008444-R04 from Novus Biologicals
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DYRK3 - MBS8206083 from MyBioSource
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shRNA set against Human DYRK3 (NM_003582.2) - SHH282301 from Creative biogene
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shRNA set against Human DYRK3(NM_001004023.1) - SHH020927 from Creative biogene
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shRNA set against Human DYRK3(NM_003582.2) - SHH020981 from Creative biogene
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