Gene Symbol | MYOG |
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Entrez Gene | 4656 |
Alt Symbol | MYF4, bHLHc3, myf-4 |
Species | Human |
Gene Type | protein-coding |
Description | myogenin (myogenic factor 4) |
Other Description | class C basic helix-loop-helix protein 3|myogenic factor 4|myogenin |
Swissprots | P15173 Q53XW6 |
Accessions | AAG22573 CAA44080 CAI58665 CAI61685 CBY88748 CBY88752 EAW91463 EAW91464 P15173 AW469592 BC053899 AAH53899 BF204429 BT007233 AAP35897 EU831793 ACE87311 EU831870 ACE86629 X17651 CAA35641 NM_002479 NP_002470 |
Function | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic lat |
Subcellular Location | Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin- remodeling and transcription initiation in developing embryos. {ECO:0000250}. |
myogenin (F5D) - sc-12732 from Santa Cruz Biotechnology
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myogenin (G-3) - sc-398002 from Santa Cruz Biotechnology
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myogenin (M-225) - sc-576 from Santa Cruz Biotechnology
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myogenin (D-10) - sc-13137 from Santa Cruz Biotechnology
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myogenin (N-20) - sc-31943 from Santa Cruz Biotechnology
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myogenin (G-20) - sc-31945 from Santa Cruz Biotechnology
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myogenin (5FD) - sc-52903 from Santa Cruz Biotechnology
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Anti-Myogenin antibody - ab82843 from Abcam
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Anti-Myogenin antibody - ab36758 from Abcam
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Anti-Myogenin antibody [EPR4789] - ab124800 from Abcam
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Anti-Myogenin antibody [F12B] - ab80956 from Abcam
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Anti-Myogenin antibody [SPM144] - ab15232 from Abcam
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Anti-Myogenin antibody [SPM144], prediluted - ab15233 from Abcam
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Anti-MYOG / Myogenin Antibody (aa30-224) - LS-C25724 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody - LS-C26709 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (clone F12B, Azide-free) - LS-C87598 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (aa30-224, clone F12B) - LS-C137364 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (aa158-178, clone F12B) - LS-C87597 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (aa138-158, clone F5D) - LS-C87542 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (clone F5D) - LS-C95519 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (aa193-206) - LS-C113013 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody - LS-C189113 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (aa30-224, clone SPM144) - LS-C189112 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (aa124-224, clone TS106) - LS-C191468 from LifeSpan Bioscience
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Anti-MYOG / Myogenin Antibody (aa124-224, clone 1D4B) - LS-C189818 from LifeSpan Bioscience
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