Gene Symbol | MYOG |
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Entrez Gene | 4656 |
Alt Symbol | MYF4, bHLHc3, myf-4 |
Species | Human |
Gene Type | protein-coding |
Description | myogenin (myogenic factor 4) |
Other Description | class C basic helix-loop-helix protein 3|myogenic factor 4|myogenin |
Swissprots | P15173 Q53XW6 |
Accessions | AAG22573 CAA44080 CAI58665 CAI61685 CBY88748 CBY88752 EAW91463 EAW91464 P15173 AW469592 BC053899 AAH53899 BF204429 BT007233 AAP35897 EU831793 ACE87311 EU831870 ACE86629 X17651 CAA35641 NM_002479 NP_002470 |
Function | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic lat |
Subcellular Location | Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin- remodeling and transcription initiation in developing embryos. {ECO:0000250}. |
Human Myogenin full length protein - ab114244 from Abcam
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MYOG / Myogenin Antibody Blocking Peptide - LS-E1726 from LifeSpan Bioscience
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MYOG / Myogenin Antibody Blocking Peptide - LS-E2735 from LifeSpan Bioscience
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MYOG / Myogenin Antibody Blocking Peptide - LS-E3730 from LifeSpan Bioscience
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MYOG / Myogenin Antibody Blocking Peptide - LS-E27332 from LifeSpan Bioscience
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Recombinant Human Myogenin Protein - H00004656-P01 from Novus Biologicals
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MYOGENIN-Antibody-N-term-Blocking-peptide - BP12509a from Abgent, a WuXi AppTec company
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MYOG-Antibody-N-term-Blocking-peptide - BP13822a from Abgent, a WuXi AppTec company
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MYOG-Antibody-Center-Blocking-Peptide - BP14940c from Abgent, a WuXi AppTec company
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Myogenin blocking peptide - GTX88097-PEP from GeneTex
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Human Myogenin (HEK293 Lysate) - orb197728 from Biorbyt
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Myogenin Peptide - AC21-2156-P from Abcore
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Myogenin - H00004656-P01-10 from Acris Antibodies
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Myogenin - H00004656-P01-25 from Acris Antibodies
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Recombinant Human Myogenin (HEK293 Lysate) - 230-10021 from RayBiotech
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Recombinant Human Myogenin - 230-00679-10 from RayBiotech
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Recombinant Human Myogenin - 230-00679-50 from RayBiotech
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Recombinant Human Myogenin - 230-00679-100 from RayBiotech
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MYOG Peptide - 42-558P from ProSci
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Myogenin fusion protein - Ag6414 from Proteintech Group
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Myogenin fusion protein - ag6109 from Proteintech Group
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Recombinant Human Myogenin (Myogenic Factor 4) - MYOG-164H from Creative Biomart
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Recombinant Human MYOG - MYOG-30274TH from Creative Biomart
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Recombinant Human MYOG - MYOG-288H from Creative Biomart
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Recombinant Myogenin (MYOG) - RPB109Hu01 from Uscn Life Science Inc.
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