| Gene Symbol |
MYOG
|
| Entrez Gene |
4656
|
| Alt Symbol |
MYF4, bHLHc3, myf-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myogenin (myogenic factor 4)
|
| Other Description |
class C basic helix-loop-helix protein 3|myogenic factor 4|myogenin
|
| Swissprots |
P15173 Q53XW6
|
| Accessions |
AAG22573 CAA44080 CAI58665 CAI61685 CBY88748 CBY88752 EAW91463 EAW91464 P15173 AW469592 BC053899 AAH53899 BF204429 BT007233 AAP35897 EU831793 ACE87311 EU831870 ACE86629 X17651 CAA35641 NM_002479 NP_002470
|
| Function |
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic lat
|
| Subcellular Location |
Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin- remodeling and transcription initiation in developing embryos. {ECO:0000250}.
|