| Gene Symbol | MYOG |
|---|---|
| Entrez Gene | 4656 |
| Alt Symbol | MYF4, bHLHc3, myf-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | myogenin (myogenic factor 4) |
| Other Description | class C basic helix-loop-helix protein 3|myogenic factor 4|myogenin |
| Swissprots | P15173 Q53XW6 |
| Accessions | AAG22573 CAA44080 CAI58665 CAI61685 CBY88748 CBY88752 EAW91463 EAW91464 P15173 AW469592 BC053899 AAH53899 BF204429 BT007233 AAP35897 EU831793 ACE87311 EU831870 ACE86629 X17651 CAA35641 NM_002479 NP_002470 |
| Function | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic lat |
| Subcellular Location | Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin- remodeling and transcription initiation in developing embryos. {ECO:0000250}. |