MYOG
| Gene Symbol | MYOG |
|---|---|
| Entrez Gene | 4656 |
| Alt Symbol | MYF4, bHLHc3, myf-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | myogenin (myogenic factor 4) |
| Other Description | class C basic helix-loop-helix protein 3|myogenic factor 4|myogenin |
| Swissprots | P15173 Q53XW6 |
| Accessions | AAG22573 CAA44080 CAI58665 CAI61685 CBY88748 CBY88752 EAW91463 EAW91464 P15173 AW469592 BC053899 AAH53899 BF204429 BT007233 AAP35897 EU831793 ACE87311 EU831870 ACE86629 X17651 CAA35641 NM_002479 NP_002470 |
| Function | Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic lat |
| Subcellular Location | Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin- remodeling and transcription initiation in developing embryos. {ECO:0000250}. |
myogenin CRISPR/Cas9 KO Plasmid (h) - sc-400176 from Santa Cruz Biotechnology
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myogenin HDR Plasmid (h) - sc-400176-HDR from Santa Cruz Biotechnology
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myogenin Double Nickase Plasmid (h) - sc-400176-NIC from Santa Cruz Biotechnology
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myogenin Double Nickase Plasmid (h2) - sc-400176-NIC-2 from Santa Cruz Biotechnology
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myogenin CRISPR Activation Plasmid (h) - sc-400176-ACT from Santa Cruz Biotechnology
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myogenin CRISPR Activation Plasmid (h2) - sc-400176-ACT-2 from Santa Cruz Biotechnology
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myogenin Lentiviral Activation Particles (h) - sc-400176-LAC from Santa Cruz Biotechnology
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myogenin Lentiviral Activation Particles (h2) - sc-400176-LAC-2 from Santa Cruz Biotechnology
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myogenin siRNA (h) - sc-29402 from Santa Cruz Biotechnology
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myogenin shRNA Plasmid (h) - sc-29402-SH from Santa Cruz Biotechnology
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myogenin shRNA (h) Lentiviral Particles - sc-29402-V from Santa Cruz Biotechnology
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Myogenin RNAi - H00004656-R01V from Novus Biologicals
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Myogenin RNAi - H00004656-R01 from Novus Biologicals
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MISSION® esiRNA - EHU138681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14873 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14873 from Sigma-Aldrich
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MYOG siRNA (Human) - CRH3078 from Cohesion Biosciences
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shRNA set against Human MYOG (NM_002479.5) - SHH348404 from Creative biogene
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Human MYOG siRNA - orb263580 from Biorbyt
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MYOG shRNA Plasmid (Human) - CHH3078 from Cohesion Biosciences
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MYOG miRNA 3'UTR clone - MiUTR4H-TG05794 from Creative biogene
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