FBXL3

Gene Symbol FBXL3
Entrez Gene 26224
Alt Symbol FBL3, FBL3A, FBXL3A
Species Human
Gene Type protein-coding
Description F-box and leucine-rich repeat protein 3
Other Description F-box and leucine-rich repeat protein 3A|F-box protein Fbl3a|F-box/LRR-repeat protein 3|F-box/LRR-repeat protein 3A
Swissprots Q9P122 B2RB04 Q9UKT7
Accessions EAW80563 Q9UKT7 AF126028 AAF37383 AF129532 AAF04466 AI133484 AK025484 AK314442 BAG37051 AL833187 BC063796 BC072448 AAH72448 DA119701 HQ447499 ADQ31985 XM_005266336 XP_005266393 XM_005266337 XP_005266394 XM_011535036 XP_011533338 XM_011535037 XP_011533339 NM_012158 NP_036290
Function Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. {ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10531035}. Cytoplasm {ECO:0000269|PubMed:10531035}. Note=Predominantly nuclear.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10531035}.
Top Pathways Circadian rhythm

Anti-FBXL3 antibody - ab96645 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FBXL3 antibody (ab96645) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-FBXL3 antibody - ab76787 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL3 antibody - ab77200 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-FBXL3 antibody (ab77200) at 1/500 dilution + HeLa cell lysate at 25 µgSecondaryHRP-conjugated goat anti-mouse IgG at 1/2500 dilutiondeveloped using the ECL technique

Anti-FBXL3 antibody - ab57306 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57306 FBXL3 antibody at 1ug/ml.

Anti-FBXL3 antibody - C-terminal - ab189794 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FBXL3 antibody - C-terminal (ab189794) at 1/500 dilutionLane 1 : Mouse brain total cell extractLane 2 : Mouse thymus total cell extractLane 3 : HeLa total cell extractLane 4 : Jurkat total cell extract

Anti-FBXL3 Antibody (aa239-288) - LS-C145919 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FBXL3 antibody LS-C145919 Western blot of Mouse Kidney lysate. Antibody concentration 1 ug/ml.

Anti-FBXL3 Antibody (aa1-5) - LS-C205113 from LifeSpan Bioscience

Prices $265.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot of extracts from NIH/3T3 cells using FBXL3 antibody.

Anti-FBXL3 Antibody (aa144-193) - LS-C110757 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FBXL3 antibody LS-C110757 Western blot of Fetal Liver lysate.

Anti-FBXL3 Antibody (clone 1A3) - LS-C139268 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A3
FBXL3 monoclonal antibody (M03), clone 1A3. Western blot of FBXL3 expression in Raw 264.7.

Anti-FBXL3 Antibody (aa14-309) - LS-C186175 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of paraformaldehyde-fixed A431 using FBXL3 antibody at 1:200 dilution.

Anti-FBXL3 Antibody (aa2-15) IHC-plus™ - LS-B2770 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-FBXL3 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2770 concentration 5 ug/ml.

Anti-FBXL3 Antibody (C-Terminus) - LS-C144941 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FBXL3 Antibody - NBP2-32527 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunohistochemistry: FBXL3 Antibody [NBP2-32527] - fallopian tube

FBXL3 Antibody - NBP1-53021 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

FBXL3 Antibody (1A3) - H00026224-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A3

FBXL3 Antibody - NBP1-32979 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FBXL3 Antibody [NBP1-32979] - Sample (30 ug of whole cell lysate) A: Molt-4 10% SDS PAGE; antibody diluted at 1:1000.

FBXL3 Antibody - NB100-53784 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: FBXL3 Antibody [NB100-53784] - Analysis of FBXL3 in human Adipose lysate using NB100-53784. Primary incubation was 1 hour. Detected by chemiluminescence.

FBXL3 Antibody (3C4) - H00026224-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C4
Sandwich ELISA: FBXL3 Antibody (3C4) [H00026224-M01] - Detection limit for recombinant GST tagged FBXL3 is approximately 1ng/ml as a capture antibody.

FBXL3 Antibody - H00026224-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

FBXL3 Polyclonal Antibody - bs-8467R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL3 antibody produced in rabbit - SAB2100777 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-FBXL3: <B>Cat. No.SAB2100777</B>: FBXL3 in Fetal Liver tissue lysate with FBXL3 antibody at 1.0 μg/mL.

Monoclonal Anti-FBXL3 antibody produced in mouse - WH0026224M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C4
<B>Immunoblotting</B><BR/>Monoclonal Anti-FBXL3, <B>Cat. No. WH0026224M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

Anti-FBXL3 antibody produced in goat - SAB2500389 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-FBXL3: <B>Cat. No. SAB2500389</B>: (1 μg/mL) staining of Human Adipose lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-FBXL3 antibody produced in rabbit - HPA060297 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FBXL3: <B>Cat. No. HPA060297</B>: Immunohistochemical staining of Human bone marrow shows moderate cytoplasmic positivity in hematopoietic cells.

Monoclonal Anti-FBXL3, (N-terminal) antibody produced in mouse - SAB1405006 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A3
<B>Immunoblotting</B><BR/>Monoclonal Anti-FBXL3: <B>Cat. No. SAB1405006</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~48.7 kDa using HeLa lysate.
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