FBXL3

Gene Symbol FBXL3
Entrez Gene 26224
Alt Symbol FBL3, FBL3A, FBXL3A
Species Human
Gene Type protein-coding
Description F-box and leucine-rich repeat protein 3
Other Description F-box and leucine-rich repeat protein 3A|F-box protein Fbl3a|F-box/LRR-repeat protein 3|F-box/LRR-repeat protein 3A
Swissprots Q9P122 B2RB04 Q9UKT7
Accessions EAW80563 Q9UKT7 AF126028 AAF37383 AF129532 AAF04466 AI133484 AK025484 AK314442 BAG37051 AL833187 BC063796 BC072448 AAH72448 DA119701 HQ447499 ADQ31985 XM_005266336 XP_005266393 XM_005266337 XP_005266394 XM_011535036 XP_011533338 XM_011535037 XP_011533339 NM_012158 NP_036290
Function Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. {ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10531035}. Cytoplasm {ECO:0000269|PubMed:10531035}. Note=Predominantly nuclear.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10531035}.
Top Pathways Circadian rhythm

FBL3A CRISPR/Cas9 KO Plasmid (h) - sc-411900 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3A HDR Plasmid (h) - sc-411900-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3A Double Nickase Plasmid (h) - sc-411900-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3A Double Nickase Plasmid (h2) - sc-411900-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3A CRISPR Activation Plasmid (h) - sc-411900-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3A CRISPR Activation Plasmid (h2) - sc-411900-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3A Lentiviral Activation Particles (h) - sc-411900-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3A Lentiviral Activation Particles (h2) - sc-411900-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3A siRNA (h) - sc-62296 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL3A shRNA Plasmid (h) - sc-62296-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL3A shRNA (h) Lentiviral Particles - sc-62296-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXL3 RNAi - H00026224-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU072621 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8526 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8526 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10537 from Sigma-Aldrich

Category miRNA

FBXL3 siRNA (Human) - CRH8761 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBXL3 - MBS8226625 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FBXL3 (NM_012158.2) - SHH292953 from Creative biogene

Category siRNA
Species Reactivities Human

FBXL3 shRNA Plasmid (Human) - CHH8761 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBXL3 miRNA 3'UTR clone - MiUTR3H-07859 from Creative biogene

Species Reactivities Human
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