FBXL3

Gene Symbol	FBXL3
Entrez Gene	26224
Alt Symbol	FBL3, FBL3A, FBXL3A
Species	Human
Gene Type	protein-coding
Description	F-box and leucine-rich repeat protein 3
Other Description	F-box and leucine-rich repeat protein 3A|F-box protein Fbl3a|F-box/LRR-repeat protein 3|F-box/LRR-repeat protein 3A
Swissprots	Q9P122 B2RB04 Q9UKT7
Accessions	EAW80563 Q9UKT7 AF126028 AAF37383 AF129532 AAF04466 AI133484 AK025484 AK314442 BAG37051 AL833187 BC063796 BC072448 AAH72448 DA119701 HQ447499 ADQ31985 XM_005266336 XP_005266393 XM_005266337 XP_005266394 XM_011535036 XP_011533338 XM_011535037 XP_011533339 NM_012158 NP_036290
Function	Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. {ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10531035}. Cytoplasm {ECO:0000269|PubMed:10531035}. Note=Predominantly nuclear.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10531035}.
Top Pathways	Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBXL3 full length protein - ab161929 from Abcam Category Protein Source Wheat germ Species Human

Human FBXL3 protein fragment - ab161930 from Abcam Category Protein Source Wheat germ Species Human

FBXL3 Antibody Blocking Peptide - LS-E15867 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBXL3 Antibody Blocking Peptide - LS-E15866 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FBXL3 Antibody Blocking Peptide - LS-E26160 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FBXL3 Protein - H00026224-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human FBXL3 Protein - H00026224-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FBXL3 blocking peptide - GTX89255-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

FBXL3 Blocking Peptide - 33R-5067 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBXL3 Peptide - AC21-0990-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FBXL3 - H00026224-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

FBXL3 - H00026224-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBXL3 - H00026224-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FBXL3 Peptide - 45-577P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant F-Box And Leucine Rich Repeat Protein 3 (FBXL3) - RPJ121Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant F-Box And Leucine Rich Repeat Protein 3 (FBXL3) - RPJ121Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human F-box/LRR-repeat protein 3(FBXL3) - CSB-YP890739HU CSB-EP890739HU CSB-BP890739HU CSB-MP890739HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBXL3, Peptide - MBS426579 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig

Recombinant Human FBXL3 protein, GST-tagged - FBXL3-32H from Creative Biomart Category Protein Source Wheat Germ Species Human

FBXL3 Peptide, Human - M34GP05578H from Creative Peptides Category Peptide Source Synthetic. Species Human

F-Box And Leucine Rich Repeat Protein 3, Recombinant Protein - MBS2029277 from MyBioSource Category Protein Prices $190.00, $405.00, $625.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

F-box/LRR-repeat protein 3 (FBXL3), Recombinant Protein - MBS1401410 from MyBioSource Category Protein Prices $1,205.00, $1,205.00, $1,425.00, $1,425.00, $1,945.00, $1,945.00, $2,410.00, $2,410.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

FBXL3 Recombinant Protein Antigen - NBP2-56645PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

FBXL3 Immunizing peptide - orb16108 from Biorbyt Category Peptide

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