| Gene Symbol |
FBXL3
|
| Entrez Gene |
26224
|
| Alt Symbol |
FBL3, FBL3A, FBXL3A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and leucine-rich repeat protein 3
|
| Other Description |
F-box and leucine-rich repeat protein 3A|F-box protein Fbl3a|F-box/LRR-repeat protein 3|F-box/LRR-repeat protein 3A
|
| Swissprots |
Q9P122 B2RB04 Q9UKT7
|
| Accessions |
EAW80563 Q9UKT7 AF126028 AAF37383 AF129532 AAF04466 AI133484 AK025484 AK314442 BAG37051 AL833187 BC063796 BC072448 AAH72448 DA119701 HQ447499 ADQ31985 XM_005266336 XP_005266393 XM_005266337 XP_005266394 XM_011535036 XP_011533338 XM_011535037 XP_011533339 NM_012158 NP_036290
|
| Function |
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. {ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10531035}. Cytoplasm {ECO:0000269|PubMed:10531035}. Note=Predominantly nuclear.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10531035}.
|
| Top Pathways |
Circadian rhythm
|
![Western Blot: FBXL3 Overexpression Lysate (Adult Normal) [NBP2-04326] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FBXL3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8049_FBXL3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04326-img0001.jpg)