| Gene Symbol |
PBK
|
| Entrez Gene |
55872
|
| Alt Symbol |
CT84, HEL164, Nori-3, SPK, TOPK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PDZ binding kinase
|
| Other Description |
MAPKK-like protein kinase|T-LAK cell-originated protein kinase|cancer/testis antigen 84|epididymis luminal protein 164|lymphokine-activated killer T-cell-originated protein kinase|serine/threonine protein kinase|spermatogenesis-related protein kinase
|
| Swissprots |
Q96KB5 B4DX68 Q9NPD9 Q9NZK6 Q9NYL7 D3DST2
|
| Accessions |
CAD43677 EAW63536 EAW63537 Q96KB5 AB027249 BAA99576 AB027250 BAA99577 AF189722 AAF69107 AF237709 AAF71521 AK027291 BAB55019 AK301836 BAG63280 BC015191 AAH15191 BI461026 DB028500 DQ893142 ABM84068 DQ896427 ABM87426 EU794685 ACJ13739 XM_006716368 XP_006716431 NM_001278945 NP_001265874 NM_018492 NP_060962
|
| Function |
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}.
|
| Tissue Specificity |
Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:11378444}.
|
![Western Blot: PBK Overexpression Lysate (Adult Normal) [NBL1-14135] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PBK.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5659_PBK%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14135-img0002.jpg)