Gene Symbol | PBK |
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Entrez Gene | 55872 |
Alt Symbol | CT84, HEL164, Nori-3, SPK, TOPK |
Species | Human |
Gene Type | protein-coding |
Description | PDZ binding kinase |
Other Description | MAPKK-like protein kinase|T-LAK cell-originated protein kinase|cancer/testis antigen 84|epididymis luminal protein 164|lymphokine-activated killer T-cell-originated protein kinase|serine/threonine protein kinase|spermatogenesis-related protein kinase |
Swissprots | Q96KB5 B4DX68 Q9NPD9 Q9NZK6 Q9NYL7 D3DST2 |
Accessions | CAD43677 EAW63536 EAW63537 Q96KB5 AB027249 BAA99576 AB027250 BAA99577 AF189722 AAF69107 AF237709 AAF71521 AK027291 BAB55019 AK301836 BAG63280 BC015191 AAH15191 BI461026 DB028500 DQ893142 ABM84068 DQ896427 ABM87426 EU794685 ACJ13739 XM_006716368 XP_006716431 NM_001278945 NP_001265874 NM_018492 NP_060962 |
Function | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
Tissue Specificity | Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:11378444}. |
Active human PBK full length protein - ab85275 from Abcam
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Active human PBK full length protein - ab70619 from Abcam
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Human PBK full length protein - ab123196 from Abcam
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Human PBK full length protein - ab190388 from Abcam
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PBK / TOPK Antibody Blocking Peptide - LS-E8733 from LifeSpan Bioscience
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PBK / TOPK Antibody Blocking Peptide - LS-E17660 from LifeSpan Bioscience
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PBK / TOPK Antibody Blocking Peptide - LS-E6635 from LifeSpan Bioscience
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PBK Recombinant Protein - H00055872-P01 from Novus Biologicals
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PBK Partial Recombinant Protein - H00055872-Q01 from Novus Biologicals
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PBK Partial Recombinant Protein - H00055872-Q02 from Novus Biologicals
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PBK Recombinant Protein - P4746 from Novus Biologicals
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Recombinant Human PBK Protein - NBP1-99082 from Novus Biologicals
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PBK Peptide - P2326 from Novus Biologicals
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PBK Peptide - P2325 from Novus Biologicals
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Phospho-PBKT9-Antibody-Blocking-peptide - BP3633a from Abgent, a WuXi AppTec company
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Phospho-PBKY74-Antibody-Blocking-peptide - BP3577a from Abgent, a WuXi AppTec company
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PBK-Antibody-Y74-Blocking-Peptide - BP7164f from Abgent, a WuXi AppTec company
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PBK-Antibody-C-term-C300-Blocking-Peptide - BP7164e from Abgent, a WuXi AppTec company
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PBK-Antibody-C-term-Blocking-Peptide - BP7164b from Abgent, a WuXi AppTec company
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PBK-Antibody-N-term-Blocking-Peptide - BP7164a from Abgent, a WuXi AppTec company
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Human PBK protein - orb168994 from Biorbyt
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Human PBK His tag protein - orb83401 from Biorbyt
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PBK Blocking Peptide - 33R-8581 from Fitzgerald
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PBK / TOPK (1-322, His-tag) - AR50262PU-N from Acris Antibodies
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PBK / TOPK (1-322, His-tag) - AR50262PU-S from Acris Antibodies
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