Gene Symbol | PBK |
---|---|
Entrez Gene | 55872 |
Alt Symbol | CT84, HEL164, Nori-3, SPK, TOPK |
Species | Human |
Gene Type | protein-coding |
Description | PDZ binding kinase |
Other Description | MAPKK-like protein kinase|T-LAK cell-originated protein kinase|cancer/testis antigen 84|epididymis luminal protein 164|lymphokine-activated killer T-cell-originated protein kinase|serine/threonine protein kinase|spermatogenesis-related protein kinase |
Swissprots | Q96KB5 B4DX68 Q9NPD9 Q9NZK6 Q9NYL7 D3DST2 |
Accessions | CAD43677 EAW63536 EAW63537 Q96KB5 AB027249 BAA99576 AB027250 BAA99577 AF189722 AAF69107 AF237709 AAF71521 AK027291 BAB55019 AK301836 BAG63280 BC015191 AAH15191 BI461026 DB028500 DQ893142 ABM84068 DQ896427 ABM87426 EU794685 ACJ13739 XM_006716368 XP_006716431 NM_001278945 NP_001265874 NM_018492 NP_060962 |
Function | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:17482142}. |
Tissue Specificity | Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. {ECO:0000269|PubMed:10781613, ECO:0000269|PubMed:11378444}. |