Gene Symbol | FBXO5 |
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Entrez Gene | 26271 |
Alt Symbol | EMI1, FBX5, Fbxo31 |
Species | Human |
Gene Type | protein-coding |
Description | F-box protein 5 |
Other Description | F-box only protein 5|F-box protein Fbx5|early mitotic inhibitor 1 |
Swissprots | B3KNX5 Q9UGC8 Q8WV29 Q9UKT4 Q5TF47 |
Accessions | EAW47718 EAW47719 EAW47720 Q9UKT4 AF129535 AAF04469 AJ420499 AK026197 AK055221 BAG51487 AK314456 BAG37064 AY079515 AAL86610 BC018905 AAH18905 BG944882 BI838832 DB122061 DQ891922 ABM82848 DQ895106 ABM86032 XM_011535749 XP_011534051 NM_001142522 NP_001135994 NM_012177 NP_036309 |
Function | Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. {ECO:0000269|PubMed:11988738, ECO:0000269|PubMed:16921029}. |
Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle. |
Top Pathways | Oocyte meiosis |
Human FBXO5 Gene cDNA Clone - orb143148 from Biorbyt
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Human-FBXO5-cDNA-Clone - DC04765 from Abgent, a WuXi AppTec company
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FBXO5 - MBS1275860 from MyBioSource
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Mouse FBXO31 ORF clone - CDCL107291 from Creative Biomart
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Mouse FBXO31 ORF clone - CDCL107292 from Creative Biomart
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Human FBXO31 ORF clone - CDCL107293 from Creative Biomart
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Human FBXO31 ORF clone - CDCL107294 from Creative Biomart
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Human FBXO31 ORF clone - CDCL107295 from Creative Biomart
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Human FBXO31 ORF clone - CDCL107296 from Creative Biomart
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Mouse FBXO31 ORF clone - CDCL107297 from Creative Biomart
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Mouse FBXO31 ORF clone - CDCL107298 from Creative Biomart
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Mouse FBXO31 ORF clone - CDCL107299 from Creative Biomart
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Mouse FBXO31 ORF clone - CDCL107300 from Creative Biomart
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Human FBXO5 cDNA clone(NM_001142522.1) - CDFH006697 from Creative Biomart
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Human FBXO5 ORF Clone(NM_001142522.1) - CDCR351418 from Creative Biomart
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Human FBXO5 ORF Clone(NM_001142522.1) - CDCR351419 from Creative Biomart
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Human FBXO5 ORF Clone(NM_001142522.1) - CDCL163299 from Creative Biomart
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Mouse FBXO5 ORF clone - CDCL107413 from Creative Biomart
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Mouse FBXO5 ORF clone - CDCL107414 from Creative Biomart
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Human FBXO5 ORF clone - CDCL107415 from Creative Biomart
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Human FBXO5 ORF clone - CDCL107416 from Creative Biomart
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Human FBXO5 Gene cDNA clone plasmid - HG13294-G from Sino Biological
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Human Emi1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13294-NF from Sino Biological
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Human Emi1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13294-NM from Sino Biological
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Human Emi1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13294-CF from Sino Biological
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