EIF4EBP3

Gene Symbol EIF4EBP3
Entrez Gene 8637
Alt Symbol 4E-BP3, 4EBP3
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 4E binding protein 3
Other Description eIF4E-binding protein 3|eukaryotic initiation factor 4E-binding protein 3|eukaryotic translation initiation factor 4E-binding protein 3
Swissprots O60516
Accessions EAW62056 O60516 AF038869 AAC39761 BC010881 AAH10881 BC069293 AAH69293 BC073751 AAH73751 NM_003732 NP_003723
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. {ECO:0000250|UniProtKB:Q13541}.
Tissue Specificity Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. {ECO:0000269|PubMed:9593750}.
Top Pathways RNA transport

4E-BP3 (4-RY9) - sc-134232 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
4E-BP3 (4-RY9): sc-134232. Western blot analysis of 4E-BP3 expression in human 4E-BP3 transfected (A) and non-transfected (B) 293T whole cell lysates.

4E-BP3 (D-12) - sc-162463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

4E-BP3 (N-14) - sc-162464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-EIF4EBP3 antibody - ab76476 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-EIF4EBP3 antibody (ab76476) at 1 µg/ml + Recombinant tagged EIF4EBP3 protein at 0.1 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-EIF4EBP3 Antibody (aa1-101) - LS-C307370 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EIF4EBP3 Antibody (clone 3B9) - LS-C340660 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY EIF4EBP3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-EIF4EBP3 (1:2000).

EIF4EBP3 Antibody - NBP1-91867 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EIF4EBP3 Antibody [NBP1-91867] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue

EIF4EBP3 Antibody - 28560002 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ELISA: EIF4EBP3 Antibody [28560002]

EIF4EBP3 Antibody (4C1) - H00008637-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C1
Western Blot: EIF4EBP3 Antibody (4C1) [H00008637-M05] - Analysis of EIF4EBP3 expression in transfected 293T cell line by EIF4EBP3 monoclonal antibody (M05), clone 4C1. Lane 1: EIF4EBP3 transfected lysatE (10.873 KDa). Lane 2: Non-transfected lysate.

EIF4EBP3 Antibody (1E3) - H00008637-M11 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E3
ELISA: EIF4EBP3 Antibody (1E3) [H00008637-M11] - Detection limit for recombinant GST tagged EIF4EBP3 is approximately 3ng/ml as a capture antibody.

EIF4EBP3 Antibody - H00008637-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-EIF4EBP3 antibody produced in rabbit - HPA045537 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-EIF4EBP3: <B>Cat. No. HPA045537</B>: Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.

Monoclonal Anti-EIF4EBP3 antibody produced in mouse - SAB1404609 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E3
<B>Immunoblotting</B><BR/>Monoclonal Anti-EIF4EBP3: <B>Cat. No. SAB1404609</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.

Anti-EIF4EBP3 (81-95) antibody produced in rabbit - SAB1100906 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-EIF4EBP3 (81-95) : <B>Cat. No. SAB1100906</B>: Immunofluorescence of HUVEC cells using EIF4EBP3 (81-95) , Cat. No. SAB1100906 (red) at a 1:100 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

EIF4EBP3-Antibody-monoclonal-M05 - AT1878a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C1
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .

4E-BP3 antibody - H00008637-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

4E-BP3 antibody - H00008637-M05 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C1
Western Blot analysis of EIF4EBP3 expression in transfected 293T cell line by EIF4EBP3 monoclonal antibody (M05), clone 4C1.Lane 1: EIF4EBP3 transfected lysate(10.873 KDa).Lane 2: Non-transfected lysate.

4E-BP3 antibody - H00008637-M11 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E3
Detection limit for recombinant GST tagged EIF4EBP3 is approximately 3ng/ml as a capture antibody.

Anti-eIF4EBP3 (aa 1-100) polyclonal antibody - DPAB-DC3612 from Creative Diagnostics

Host Mouse
Clonality Polyclonal
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