EIF4EBP3

Gene Symbol EIF4EBP3
Entrez Gene 8637
Alt Symbol 4E-BP3, 4EBP3
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 4E binding protein 3
Other Description eIF4E-binding protein 3|eukaryotic initiation factor 4E-binding protein 3|eukaryotic translation initiation factor 4E-binding protein 3
Swissprots O60516
Accessions EAW62056 O60516 AF038869 AAC39761 BC010881 AAH10881 BC069293 AAH69293 BC073751 AAH73751 NM_003732 NP_003723
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. {ECO:0000250|UniProtKB:Q13541}.
Tissue Specificity Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. {ECO:0000269|PubMed:9593750}.
Top Pathways RNA transport

4E-BP3 CRISPR/Cas9 KO Plasmid (h) - sc-406304 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 HDR Plasmid (h) - sc-406304-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 Double Nickase Plasmid (h) - sc-406304-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 Double Nickase Plasmid (h2) - sc-406304-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 CRISPR Activation Plasmid (h) - sc-406304-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 CRISPR Activation Plasmid (h2) - sc-406304-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 Lentiviral Activation Particles (h) - sc-406304-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 Lentiviral Activation Particles (h2) - sc-406304-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 siRNA (h) - sc-91863 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

4E-BP3 shRNA Plasmid (h) - sc-91863-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

4E-BP3 shRNA (h) Lentiviral Particles - sc-91863-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EIF4EBP3 RNAi - H00008637-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU218031 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7781 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7781 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EIF4EBP3 siRNA (Human) - CRH5676 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF4EBP3 - MBS8229993 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

4E-BP3 CRISPR/Cas9 KO Plasmid (h2) - sc-406304-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

4E-BP3 HDR Plasmid (h2) - sc-406304-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human EIF4EBP3(NM_003732.2) - SHG058951 from Creative biogene

Category siRNA
Species Reactivities Human

Human EIF4EBP3 siRNA - orb266178 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF4EBP3 shRNA Plasmid (Human) - CHH5676 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EIF4EBP3 miRNA 3'UTR clone - MiUTR1H-03176 from Creative biogene

Species Reactivities Human
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