| Gene Symbol |
EIF4EBP3
|
| Entrez Gene |
8637
|
| Alt Symbol |
4E-BP3, 4EBP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 4E binding protein 3
|
| Other Description |
eIF4E-binding protein 3|eukaryotic initiation factor 4E-binding protein 3|eukaryotic translation initiation factor 4E-binding protein 3
|
| Swissprots |
O60516
|
| Accessions |
EAW62056 O60516 AF038869 AAC39761 BC010881 AAH10881 BC069293 AAH69293 BC073751 AAH73751 NM_003732 NP_003723
|
| Function |
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. {ECO:0000250|UniProtKB:Q13541}.
|
| Tissue Specificity |
Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. {ECO:0000269|PubMed:9593750}.
|
| Top Pathways |
RNA transport
|