Gene Symbol |
MSR1
|
Entrez Gene |
4481
|
Alt Symbol |
CD204, SCARA1, SR-A, SRA, phSR1, phSR2
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
macrophage scavenger receptor 1
|
Other Description |
macrophage acetylated LDL receptor I and II|macrophage scavenger receptor type III|macrophage scavenger receptor types I and II|scavenger receptor class A member 1|scavenger receptor class A, member 1
|
Swissprots |
P21759 D3DSP3 P21757 O60505 Q45F10
|
Accessions |
AAZ38715 CCQ77679 EAW63830 EAW63831 EAW63832 EAW63833 EAW63834 P21757 AF037351 AAC09251 AK293217 BAG56756 AK293409 BAG56916 BC063878 AAH63878 D13264 D13265 D90187 BAA14208 D90188 BAA14209 DA995755 HQ447469 ADQ31955 NM_002445 NP_002436 NM_138715 NP_619729 NM_138716 NP_619730
|
Function |
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
|
Subcellular Location |
Membrane; Single-pass type II membrane protein.
|
Tissue Specificity |
Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. {ECO:0000269|PubMed:9548586}.
|
Top Pathways |
Phagosome
|