MSR1
| Gene Symbol | MSR1 |
|---|---|
| Entrez Gene | 4481 |
| Alt Symbol | CD204, SCARA1, SR-A, SRA, phSR1, phSR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | macrophage scavenger receptor 1 |
| Other Description | macrophage acetylated LDL receptor I and II|macrophage scavenger receptor type III|macrophage scavenger receptor types I and II|scavenger receptor class A member 1|scavenger receptor class A, member 1 |
| Swissprots | P21759 D3DSP3 P21757 O60505 Q45F10 |
| Accessions | AAZ38715 CCQ77679 EAW63830 EAW63831 EAW63832 EAW63833 EAW63834 P21757 AF037351 AAC09251 AK293217 BAG56756 AK293409 BAG56916 BC063878 AAH63878 D13264 D13265 D90187 BAA14208 D90188 BAA14209 DA995755 HQ447469 ADQ31955 NM_002445 NP_002436 NM_138715 NP_619729 NM_138716 NP_619730 |
| Function | Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL. |
| Subcellular Location | Membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. {ECO:0000269|PubMed:9548586}. |
| Top Pathways | Phagosome |
SR-A CRISPR/Cas9 KO Plasmid (h) - sc-401898 from Santa Cruz Biotechnology
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SR-A HDR Plasmid (h) - sc-401898-HDR from Santa Cruz Biotechnology
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SR-A Double Nickase Plasmid (h) - sc-401898-NIC from Santa Cruz Biotechnology
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SR-A Double Nickase Plasmid (h2) - sc-401898-NIC-2 from Santa Cruz Biotechnology
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SR-A CRISPR Activation Plasmid (h) - sc-401898-ACT from Santa Cruz Biotechnology
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SR-A CRISPR Activation Plasmid (h2) - sc-401898-ACT-2 from Santa Cruz Biotechnology
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SR-A Lentiviral Activation Particles (h) - sc-401898-LAC from Santa Cruz Biotechnology
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SR-A Lentiviral Activation Particles (h2) - sc-401898-LAC-2 from Santa Cruz Biotechnology
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SR-A siRNA (h) - sc-44116 from Santa Cruz Biotechnology
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SR-A shRNA Plasmid (h) - sc-44116-SH from Santa Cruz Biotechnology
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SR-A shRNA (h) Lentiviral Particles - sc-44116-V from Santa Cruz Biotechnology
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SR-AI/MSR RNAi - H00004481-R03 from Novus Biologicals
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SR-AI/MSR RNAi - H00004481-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN2531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2531 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11103 from Sigma-Aldrich
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MSR1 siRNA (Human) - CRH2975 from Cohesion Biosciences
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SR-AI/MSR RNAi - H00004481-R02 from Novus Biologicals
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shRNA set against Human MSR1 (NM_002445.3) - SHH345796 from Creative biogene
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shRNA set against Human MSR1(NM_002445.3) - SHH204097 from Creative biogene
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shRNA set against Human MSR1(NM_138715.2) - SHH204115 from Creative biogene
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shRNA set against Human MSR1(NM_138716.2) - SHH204149 from Creative biogene
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Human MSR1 siRNA - orb263477 from Biorbyt
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MSR1 shRNA Plasmid (Human) - CHH2975 from Cohesion Biosciences
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MSR1 miRNA 3'UTR clone - MiUTR1H-06482 from Creative biogene
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