| Gene Symbol |
ATG4D
|
| Entrez Gene |
84971
|
| Alt Symbol |
APG4-D, APG4D, AUTL4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
autophagy related 4D, cysteine peptidase
|
| Other Description |
APG4 autophagy 4 homolog D|ATG4 autophagy related 4 homolog D|AUT-like 4 cysteine endopeptidase|autophagin-4|autophagy-related cysteine endopeptidase 4|autophagy-related protein 4 homolog D|cysteine protease ATG4D|cysteine protease involved in autophagy
|
| Swissprots |
Q969K0 Q86TL0
|
| Accessions |
EAW84116 EAW84117 EAW84118 EAW84119 Q86TL0 AJ312332 CAC85951 AK056210 BAB71121 AK223383 BAD97103 AK294676 BAG57839 AK314712 AK316454 BAH14825 BC007639 AAH07639 BC016845 AAH16845 BC068992 AAH68992 BM671285 HQ447598 ADQ32084 HY063028 JF432562 ADZ15779 XM_006722927 XP_006722990 NM_001281504 NP_001268433 NM_032885 NP_116274 NR_104024 NR_104025
|
| Function |
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
|
| Subcellular Location |
Cysteine protease ATG4D: Cytoplasm.
|
| Tissue Specificity |
Mainly expressed in skeletal muscle and, to a lower extent, in testis. {ECO:0000269|PubMed:12446702}.
|
| Top Pathways |
Regulation of autophagy
|