ATG4D

Gene Symbol ATG4D
Entrez Gene 84971
Alt Symbol APG4-D, APG4D, AUTL4
Species Human
Gene Type protein-coding
Description autophagy related 4D, cysteine peptidase
Other Description APG4 autophagy 4 homolog D|ATG4 autophagy related 4 homolog D|AUT-like 4 cysteine endopeptidase|autophagin-4|autophagy-related cysteine endopeptidase 4|autophagy-related protein 4 homolog D|cysteine protease ATG4D|cysteine protease involved in autophagy
Swissprots Q969K0 Q86TL0
Accessions EAW84116 EAW84117 EAW84118 EAW84119 Q86TL0 AJ312332 CAC85951 AK056210 BAB71121 AK223383 BAD97103 AK294676 BAG57839 AK314712 AK316454 BAH14825 BC007639 AAH07639 BC016845 AAH16845 BC068992 AAH68992 BM671285 HQ447598 ADQ32084 HY063028 JF432562 ADZ15779 XM_006722927 XP_006722990 NM_001281504 NP_001268433 NM_032885 NP_116274 NR_104024 NR_104025
Function Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Subcellular Location Cysteine protease ATG4D: Cytoplasm.
Tissue Specificity Mainly expressed in skeletal muscle and, to a lower extent, in testis. {ECO:0000269|PubMed:12446702}.
Top Pathways Regulation of autophagy

Atg4D CRISPR/Cas9 KO Plasmid (h) - sc-413750 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg4D HDR Plasmid (h) - sc-413750-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg4D Double Nickase Plasmid (h) - sc-413750-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg4D Double Nickase Plasmid (h2) - sc-413750-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg4D CRISPR Activation Plasmid (h) - sc-413750-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg4D CRISPR Activation Plasmid (h2) - sc-413750-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg4D Lentiviral Activation Particles (h) - sc-413750-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg4D Lentiviral Activation Particles (h2) - sc-413750-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Atg4D siRNA (h) - sc-97728 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Atg4D shRNA Plasmid (h) - sc-97728-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Atg4D shRNA (h) Lentiviral Particles - sc-97728-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU035721 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3654 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3654 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ATG4D siRNA (Human) - CRJ3738 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ATG4D - MBS8225828 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ATG4D (NM_032885.4) - SHH242150 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ATG4D(NM_032885.4) - SHG080029 from Creative biogene

Category siRNA
Species Reactivities Human

ATG4D shRNA Plasmid (Human) - CHJ3738 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ATG4D miRNA 3'UTR clone - MiUTR1H-00664 from Creative biogene

Species Reactivities Human
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