AFAP1

Gene Symbol AFAP1
Entrez Gene 60312
Alt Symbol AFAP, AFAP-110, AFAP110
Species Human
Gene Type protein-coding
Description actin filament associated protein 1
Other Description 110 kDa actin filament-associated protein|actin filament-associated protein 1|actin filament-associated protein, 110 kDa
Swissprots Q59EY5 E9PDT7 B4DMU2 Q8N556 Q9HBY1 A8K442
Accessions EAW82360 Q8N556 AB209676 BAD92913 AF188700 AAG17055 AK127962 BAC87209 AK290807 BAF83496 AK297631 BAG60004 AL706541 BC015900 BC032777 AAH32777 BI561136 CA448961 CN308844 D25248 DA605903 DB450895 DQ585763 XM_006713908 XP_006713971 XM_006713909 XP_006713972 XM_011513544 XP_011511846 XM_011513545 XP_011511847 XM_011513546 XP_011511848 NM_001134647 NP_001128119 NM_198595 NP_940997 NM_021638
Function Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15485829}. Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction.
Tissue Specificity Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF- 7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma. {ECO:0000269|PubMed:17520695, ECO:0000269|PubMed:17885682}.

AFAP1-Over-expression-Lysate - LY13799a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag AFAP1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the AFAP1 gene.

AFAP 293T Cell Transient Overexpression Lysate(Denatured) - H00060312-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

AFAP1 overexpression lysate - LY404799 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

AFAP1 293 Cell Lysate - 403448 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

AFAP Overexpression Lysate (Native) - NBL1-07368 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: AFAP Overexpression Lysate (Adult Normal) [NBL1-07368] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AFAP.

AFAP Overexpression Lysate (Native) - NBL1-07367 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: AFAP Overexpression Lysate (Adult Normal) [NBL1-07367] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AFAP.

AFAP-110 (h): 293T Lysate - sc-114982 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

AFAP1 Over-expression Lysate Product - GWB-DA4CB4 from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

AFAP1 Over-expression Lysate Product - GWB-CE153C from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

AFAP Overexpression Lysate (Denatured) - H00060312-T01 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human AFAP1 Knockdown Stable Cell Line - CSC-DC000347 from Creative biogene

Category Cell Line
Species Human
Search more