AFAP1

Gene Symbol	AFAP1
Entrez Gene	60312
Alt Symbol	AFAP, AFAP-110, AFAP110
Species	Human
Gene Type	protein-coding
Description	actin filament associated protein 1
Other Description	110 kDa actin filament-associated protein|actin filament-associated protein 1|actin filament-associated protein, 110 kDa
Swissprots	Q59EY5 E9PDT7 B4DMU2 Q8N556 Q9HBY1 A8K442
Accessions	EAW82360 Q8N556 AB209676 BAD92913 AF188700 AAG17055 AK127962 BAC87209 AK290807 BAF83496 AK297631 BAG60004 AL706541 BC015900 BC032777 AAH32777 BI561136 CA448961 CN308844 D25248 DA605903 DB450895 DQ585763 XM_006713908 XP_006713971 XM_006713909 XP_006713972 XM_011513544 XP_011511846 XM_011513545 XP_011511847 XM_011513546 XP_011511848 NM_001134647 NP_001128119 NM_198595 NP_940997 NM_021638
Function	Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15485829}. Note=Localizes with stress fibers in quiescent cells, concentrated in cell motility structures such as lamellipodia, filopodia and membrane ruffles upon their induction.
Tissue Specificity	Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF- 7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma. {ECO:0000269|PubMed:17520695, ECO:0000269|PubMed:17885682}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AFAP full length protein - ab163707 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human AFAP full length protein - ab163708 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human AFAP protein fragment - ab163709 from Abcam Category Protein Source Wheat germ Species Human

Human AFAP protein fragment - ab181922 from Abcam Category Protein Prices $301.00 Sizes 50 µg Source E. coli Species Human

AFAP1 / AFAP Antibody Blocking Peptide - LS-E1912 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AFAP1 / AFAP Antibody Blocking Peptide - LS-E21011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AFAP1 / AFAP Antibody Blocking Peptide - LS-E31190 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AFAP Recombinant Protein - H00060312-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

AFAP Partial Recombinant Protein - H00060312-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

AFAP Recombinant Protein - H00060312-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

AFAP1-Antibody-C-term-Blocking-peptide - BP12749b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AFAP1 Blocking Peptide - 33R-7775 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AFAP1 protein (His tag) - 80R-3826 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source E.coli

AFAP1 (250-588, His-tag) - AR51513PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

AFAP1 (250-588, His-tag) - AR51513PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

AFAP1 - H00060312-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AFAP1 - H00060312-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

AFAP1 - H00060312-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

AFAP1 - H00060312-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AFAP1 - H00060312-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AFAP1 (N-term) Control Peptide - AP55595CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

AFAP1, 250-588aa, Human, His tag, E.coli - 01-P2693 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

AFAP1 Peptide - 6557P from ProSci Category Peptide Species Human

AFAP1 fusion protein - Ag15346 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

AFAP1 fusion protein - Ag15912 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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