MB21D1

Gene Symbol MB21D1
Entrez Gene 115004
Alt Symbol C6orf150, cGAS, h-cGAS
Species Human
Gene Type protein-coding
Description Mab-21 domain containing 1
Other Description cGAMP synthase|cyclic GMP-AMP synthase|mab-21 domain-containing protein 1|protein MB21D1
Swissprots Q8N884 Q96E45 Q32NC9 Q5SWL0 L0L2J9 Q5SWL1 Q14CV6
Accessions EAW48769 Q8N884 AK097148 BAC04965 BC012928 AAH12928 BC108714 AAI08715 BC113606 AAI13607 BC113608 AAI13609 BC143694 AAI43695 DA375117 HQ258303 ADR83057 KC294566 AGB51853 XM_006715327 XP_006715390 NM_138441 NP_612450
Function Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:23258413}.
Tissue Specificity Expressed in the monocytic cell line THP1. {ECO:0000269|PubMed:23258413}.
Top Pathways Cytosolic DNA-sensing pathway

chromosome 6 open reading frame 150, ELISA Kit - MBS9332833 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/ml.
Range 0.25 ng/ml - 8 ng/ml.

Human MB21D1 ELISA Kit - E078561 from Biobool

Category ELISA Kit

anti-cGAS antibody - ARG54961 from Arigo Biolaboratories

Category ELISA Kit

Protein MB21D1 (C6ORF150), ELISA Kit - MBS9356568 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein MB21D1 (C6ORF150), ELISA Kit - MBS9349676 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein MB21D1 (C6ORF150), ELISA Kit - MBS9346869 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein MB21D1 (C6ORF150), ELISA Kit - MBS9351649 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein MB21D1 (C6ORF150), ELISA Kit - MBS9355024 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein MB21D1 (C6ORF150), ELISA Kit - MBS9363297 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein MB21D1 (C6ORF150), ELISA Kit - MBS9370872 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Search more