MB21D1

Gene Symbol	MB21D1
Entrez Gene	115004
Alt Symbol	C6orf150, cGAS, h-cGAS
Species	Human
Gene Type	protein-coding
Description	Mab-21 domain containing 1
Other Description	cGAMP synthase|cyclic GMP-AMP synthase|mab-21 domain-containing protein 1|protein MB21D1
Swissprots	Q8N884 Q96E45 Q32NC9 Q5SWL0 L0L2J9 Q5SWL1 Q14CV6
Accessions	EAW48769 Q8N884 AK097148 BAC04965 BC012928 AAH12928 BC108714 AAI08715 BC113606 AAI13607 BC113608 AAI13609 BC143694 AAI43695 DA375117 HQ258303 ADR83057 KC294566 AGB51853 XM_006715327 XP_006715390 NM_138441 NP_612450
Function	Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:23258413}.
Tissue Specificity	Expressed in the monocytic cell line THP1. {ECO:0000269|PubMed:23258413}.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

C6orf150 / MB21D1 Antibody Blocking Peptide - LS-E272 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CF150-Antibody-Center-Blocking-Peptide - BP10510c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

C6ORF150 Blocking Peptide - 33R-9732 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

C6orf150 - H00115004-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Recombinant Mab21 Domain Containing Protein 1 (MB21D1) - RPU056Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mab21 Domain Containing Protein 1 (MB21D1) - RPU056Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mab21 Domain Containing Protein 1 (MB21D1) - RPU056Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Protein MB21D1(MB21D1) - CSB-YP822726HU CSB-EP822726HU CSB-BP822726HU CSB-MP822726HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human cGAS Protein - H00115004-P01-2ug from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

MB21D1 Peptide - abx164714 from Abbexa Category Peptide Species Human, Mouse, Rat

C6orf150 - TP312386 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

C6orf150 fusion protein - Ag23455 from Proteintech Group Category Protein Species Human

MB21D1 protein - 80-1573 from Fitzgerald Category Protein Source Yeast

cGAS Recombinant Protein Antigen - NBP1-86761PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MB21D1 Peptide, Human - M34GP09266H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Cyclic GMP-AMP synthase(MB21D1),partial - CSB-EP822726HU from Cusabio Category Protein Source E.coli Species Human

MB21D1 Recombinant Protein (OPCD05149) - OPCD05149 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant Human Cyclic GMP-AMP synthase(MB21D1),partial - AP74031 from Signalway Antibody Category Protein Prices $105.00, $260.00, $454.00, $735.00, $1,240.00, $1,980.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

cGAS Recombinant Protein Antigen - NBP2-55374PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Cyclic GMP-AMP synthase (MB21D1), Recombinant Protein - MBS9423611 from MyBioSource Category Protein Prices $165.00, $280.00, $435.00, $665.00, $1,080.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg Source E Coli Species Human

Protein MB21D1 (MB21D1), Recombinant Protein - MBS1404646 from MyBioSource Category Protein Prices $1,315.00, $1,315.00, $1,530.00, $1,530.00, $2,165.00, $2,165.00, $2,630.00, $2,630.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MB21D1 Recombinant Protein (Human) (OPCA04442) - OPCA04442 from Aviva Systems Biology Category Protein Species Human

Human MB21D1 protein - orb383249 from Biorbyt Category Protein Species Human

Recombinant Human MB21D1 Protein (161-522 aa), His-SUMO-tagged - MB21D1-2114H from Creative Biomart Category Protein Source E. coli Species Human

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