MB21D1

Gene Symbol	MB21D1
Entrez Gene	115004
Alt Symbol	C6orf150, cGAS, h-cGAS
Species	Human
Gene Type	protein-coding
Description	Mab-21 domain containing 1
Other Description	cGAMP synthase|cyclic GMP-AMP synthase|mab-21 domain-containing protein 1|protein MB21D1
Swissprots	Q8N884 Q96E45 Q32NC9 Q5SWL0 L0L2J9 Q5SWL1 Q14CV6
Accessions	EAW48769 Q8N884 AK097148 BAC04965 BC012928 AAH12928 BC108714 AAI08715 BC113606 AAI13607 BC113608 AAI13609 BC143694 AAI43695 DA375117 HQ258303 ADR83057 KC294566 AGB51853 XM_006715327 XP_006715390 NM_138441 NP_612450
Function	Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:23258413}.
Tissue Specificity	Expressed in the monocytic cell line THP1. {ECO:0000269|PubMed:23258413}.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

C6orf150-Over-expression-Lysate - LY16421a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

MB21D1 overexpression lysate - LY408695 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

C6orf150 293 Cell Lysate - 404743 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

cGAS Overexpression Lysate (Native) - NBP2-05675 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

C6orf150 Over-expression Lysate Product - GWB-7DC166 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human MB21D1 Knockdown Stable Cell Line - CSC-DC009266 from Creative biogene Category Cell Line Species Human

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