| Gene Symbol |
CDK5R1
|
| Entrez Gene |
8851
|
| Alt Symbol |
CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
|
| Other Description |
CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit
|
| Swissprots |
E1P664 Q5U0G3 Q15078
|
| Accessions |
AAQ74776 EAW80227 EAW80228 Q15078 AK095754 BC020580 AAH20580 BC026347 AAH26347 BC030792 AAH30792 BC032081 BC035448 BT019573 AAV38380 HQ448723 ADQ33201 X80343 CAA56587 XM_011525438 XP_011523740 NM_003885 NP_003876
|
| Function |
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.
|
| Subcellular Location |
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
|
| Tissue Specificity |
Brain and neuron specific.
|
| Top Pathways |
Alzheimer's disease, Cocaine addiction
|
