CDK5R1

Gene Symbol	CDK5R1
Entrez Gene	8851
Alt Symbol	CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Other Description	CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit
Swissprots	E1P664 Q5U0G3 Q15078
Accessions	AAQ74776 EAW80227 EAW80228 Q15078 AK095754 BC020580 AAH20580 BC026347 AAH26347 BC030792 AAH30792 BC032081 BC035448 BT019573 AAV38380 HQ448723 ADQ33201 X80343 CAA56587 XM_011525438 XP_011523740 NM_003885 NP_003876
Function	p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.
Subcellular Location	Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Tissue Specificity	Brain and neuron specific.
Top Pathways	Alzheimer's disease, Cocaine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human p35 full length protein - ab126931 from Abcam Category Protein Prices $239.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human p35 + p25 full length protein - ab125653 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human p35 full length protein - ab119724 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human p35 full length protein - ab160222 from Abcam Category Protein Source Wheat germ Species Human

Human p35 protein fragment - ab160223 from Abcam Category Protein Source Wheat germ Species Human

CDK5R1 Antibody Blocking Peptide - LS-E10520 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CDK5 Activator 1 Protein - H00008851-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CDK5 Activator 1 Protein - H00008851-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

CDK5R1 - H00008851-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CDK5R1 - H00008851-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CDK5R1 - H00008851-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CDK5R1 fusion protein - Ag13152 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human CDK5R1 - CDK5R1-669H from Creative Biomart Category Protein Source E. coli.

Recombinant Human CDK5R1, His-tagged - CDK5R1-11051H from Creative Biomart Category Protein Source E. coli Species Human

CDK5P25 protein-GST fusion - 009-001-R64 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

CDK5P25 protein-GST fusion - 009-001-R64S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

CDK5P35 protein-GST fusion - 009-001-R65 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

CDK5P35 protein-GST fusion - 009-001-R65S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

p35 Blocking Peptide - CBP2333 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Zebrafish

p35 (Q31) Peptide - BS2065P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Cyclin-dependent kinase 5 activator 1(CDK5R1) - CSB-YP624014HU CSB-EP624014HU CSB-BP624014HU CSB-MP624014HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CDK5P25, Recombinant Protein - MBS515301 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source Sf9 insect cells Species Human

CDK5P35, Recombinant Protein - MBS515245 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

p35, Recombinant Protein - MBS505045 from MyBioSource Category Protein Prices $400.00, $685.00, $885.00 Sizes 100 µg, 500 µg, 1 mg Source E Coli Species Toxoplasma gondii

CDK5R1p35-Antibody-C-term-Blocking-Peptide - BP7743b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Search more