Gene Symbol | CDK5R1 |
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Entrez Gene | 8851 |
Alt Symbol | CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a |
Species | Human |
Gene Type | protein-coding |
Description | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Other Description | CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit |
Swissprots | E1P664 Q5U0G3 Q15078 |
Accessions | AAQ74776 EAW80227 EAW80228 Q15078 AK095754 BC020580 AAH20580 BC026347 AAH26347 BC030792 AAH30792 BC032081 BC035448 BT019573 AAV38380 HQ448723 ADQ33201 X80343 CAA56587 XM_011525438 XP_011523740 NM_003885 NP_003876 |
Function | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}. |
Subcellular Location | Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. |
Tissue Specificity | Brain and neuron specific. |
Top Pathways | Alzheimer's disease, Cocaine addiction |
Active human p35 full length protein - ab126931 from Abcam
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Human p35 + p25 full length protein - ab125653 from Abcam
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Human p35 full length protein - ab119724 from Abcam
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Human p35 full length protein - ab160222 from Abcam
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Human p35 protein fragment - ab160223 from Abcam
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CDK5R1 Antibody Blocking Peptide - LS-E10520 from LifeSpan Bioscience
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Recombinant Human CDK5 Activator 1 Protein - H00008851-Q01 from Novus Biologicals
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Recombinant Human CDK5 Activator 1 Protein - H00008851-P01 from Novus Biologicals
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CDK5R1 - H00008851-P01 from Acris Antibodies
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CDK5R1 - H00008851-Q01-10 from Acris Antibodies
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CDK5R1 - H00008851-Q01-25 from Acris Antibodies
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CDK5R1 fusion protein - Ag13152 from Proteintech Group
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Recombinant Human CDK5R1 - CDK5R1-669H from Creative Biomart
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Recombinant Human CDK5R1, His-tagged - CDK5R1-11051H from Creative Biomart
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CDK5P25 protein-GST fusion - 009-001-R64 from Rockland Immunochemicals Inc
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CDK5P25 protein-GST fusion - 009-001-R64S from Rockland Immunochemicals Inc
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CDK5P35 protein-GST fusion - 009-001-R65 from Rockland Immunochemicals Inc
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CDK5P35 protein-GST fusion - 009-001-R65S from Rockland Immunochemicals Inc
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p35 Blocking Peptide - CBP2333 from Cohesion Biosciences
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p35 (Q31) Peptide - BS2065P from Bioworld Technology
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Recombinant Human Cyclin-dependent kinase 5 activator 1(CDK5R1) - CSB-YP624014HU CSB-EP624014HU CSB-BP624014HU CSB-MP624014HU from Cusabio
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CDK5P25, Recombinant Protein - MBS515301 from MyBioSource
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CDK5P35, Recombinant Protein - MBS515245 from MyBioSource
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p35, Recombinant Protein - MBS505045 from MyBioSource
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CDK5R1p35-Antibody-C-term-Blocking-Peptide - BP7743b from Abgent, a WuXi AppTec company
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