CDK5R1

Gene Symbol	CDK5R1
Entrez Gene	8851
Alt Symbol	CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Other Description	CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit
Swissprots	E1P664 Q5U0G3 Q15078
Accessions	AAQ74776 EAW80227 EAW80228 Q15078 AK095754 BC020580 AAH20580 BC026347 AAH26347 BC030792 AAH30792 BC032081 BC035448 BT019573 AAV38380 HQ448723 ADQ33201 X80343 CAA56587 XM_011525438 XP_011523740 NM_003885 NP_003876
Function	p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.
Subcellular Location	Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Tissue Specificity	Brain and neuron specific.
Top Pathways	Alzheimer's disease, Cocaine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CDK5R1 gene - orb91377 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-CDK5R1-cDNA-Clone - DC06159 from Abgent, a WuXi AppTec company Prices $415.80 Sizes 10 µg Species Human Accession NM_003885

CDK5R1 - MBS1269396 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC030792

CDK5R1 - MBS1273267 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC026347

CDK5R1 - MBS1272559 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC020580

Human p35/CDK5R1 Gene ORF cDNA clone in cloning vector - HG10922-M from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid - HG10922-UT from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10922-ACG from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10922-NF from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10922-NM from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10922-CF from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10922-CY from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10922-CM from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10922-ACR from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10922-NH from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10922-ANG from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10922-NY from Sino Biological Species Human

Human p35/CDK5R1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10922-CH from Sino Biological Species Human

Human CDK5R1 ORF clone(NM_003885.2) - CDCL183504 from Creative biogene Species Human

Human CDK5R1 ORF Clone (BC026347) - CDCS411529 from Creative biogene Species Human Accession Q15078

Human CDK5R1 ORF Clone (BC030792) - CDCS411531 from Creative biogene Species Human Accession Q15078

Human CDK5R1 cDNA Clone(NM_003885.2) - CDFH003323 from Creative biogene Species Human

Human CDK5R1 ORF Clone (BC020580) - CDCS411530 from Creative biogene Species Human Accession Q15078

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