CDK5R1

Gene Symbol CDK5R1
Entrez Gene 8851
Alt Symbol CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Other Description CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit
Swissprots E1P664 Q5U0G3 Q15078
Accessions AAQ74776 EAW80227 EAW80228 Q15078 AK095754 BC020580 AAH20580 BC026347 AAH26347 BC030792 AAH30792 BC032081 BC035448 BT019573 AAV38380 HQ448723 ADQ33201 X80343 CAA56587 XM_011525438 XP_011523740 NM_003885 NP_003876
Function p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.
Subcellular Location Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Tissue Specificity Brain and neuron specific.
Top Pathways Alzheimer's disease, Cocaine addiction

p35/25 (C64B10) Rabbit mAb - 2680 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C64B10
Western blot analysis of extracts from mouse brain, rat brain and human cerebellum using p35/p25 (C64B10) Rabbit mAb.

p35 Antibody - 2673 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

p35 (A-18) - sc-31102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p35 (A-18): sc-31102. Western blot analysis of p35 expression in non-transfected: sc-117752 (A) and human p35 transfected: sc-113375 (B) 293T whole cell lysates.

p35 (C-19) - sc-820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p35 (C-19): sc-820. Western blot analysis of p35 expression in HeLa whole cell lysate (A) and A-431 (B) and HeLa (C) nuclear extracts.

p35 (S-17) - sc-31103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p35 (S-17): sc-31103. Western blot analysis of p35 expression in non-transfected: sc-117752 (A) and human p35 transfected: sc-113375 (B) 293T whole cell lysates.

p35 (H-72) - sc-5614 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p35 (H-72): sc-5614. Western blot analysis of p35 expression in non-transfected: sc-117752 (A) and human p35 transfected: sc-113375 (B) 293T whole cell lysates.

p35 (N-20) - sc-821 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p35 (N-20): sc-821. Western blot analysis of p35 expression in non-transfected: sc-117752 (A) and human p35 transfected: sc-113375 (B) 293T whole cell lysates.

Anti-p35 antibody - ab66064 from Abcam

Prices $387.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
All lanes : Anti-p35 antibody (ab66064) at 1 µg/mlLane 1 : p35 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 50 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-p35 antibody - ab10570 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC image of ab10570 staining in human normal cerebral cortex formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab10570, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-p35 antibody - ab64960 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-p35 antibody (ab64960) at 1/500 dilutionLane 1 : Rat brain cell extractLane 2 : Rat brain cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-p35 antibody - ab123048 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-p35 antibody (ab123048) at 1 µg/ml + Mouse pancreas lysate at 10 µg

Anti-CDK5R1 Antibody - LS-C91154 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CDK5R1 Antibody (clone SPM348) - LS-C189137 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone SPM348

Anti-CDK5R1 Antibody (aa278-307, AP) - LS-C208333 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (aa278-307, APC) - LS-C208334 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (aa278-307, Biotin) - LS-C208335 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (aa278-307, FITC) - LS-C208336 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (aa278-307, PE) - LS-C208338 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (aa278-307, Azide-free, HRP) - LS-C208337 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (N-Terminus, AP) - LS-C208339 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (N-Terminus, APC) - LS-C208340 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (C-Terminus) - LS-C145910 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CDK5R1 / p35 antibody LS-C145910 Western blot of Mouse Pancreas lysate. Antibody concentration 1 ug/ml.

Anti-CDK5R1 Antibody (N-Terminus, Biotin) - LS-C208341 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (N-Terminus, FITC) - LS-C208342 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CDK5R1 Antibody (N-Terminus, Azide-free, HRP) - LS-C208343 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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