CDK5R1

Gene Symbol	CDK5R1
Entrez Gene	8851
Alt Symbol	CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Other Description	CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit
Swissprots	E1P664 Q5U0G3 Q15078
Accessions	AAQ74776 EAW80227 EAW80228 Q15078 AK095754 BC020580 AAH20580 BC026347 AAH26347 BC030792 AAH30792 BC032081 BC035448 BT019573 AAV38380 HQ448723 ADQ33201 X80343 CAA56587 XM_011525438 XP_011523740 NM_003885 NP_003876
Function	p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.
Subcellular Location	Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Tissue Specificity	Brain and neuron specific.
Top Pathways	Alzheimer's disease, Cocaine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

p35 CRISPR/Cas9 KO Plasmid (h) - sc-400431 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 HDR Plasmid (h) - sc-400431-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 Double Nickase Plasmid (h) - sc-400431-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 Double Nickase Plasmid (h2) - sc-400431-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 CRISPR Activation Plasmid (h) - sc-400431-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 CRISPR Activation Plasmid (h2) - sc-400431-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 Lentiviral Activation Particles (h) - sc-400431-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 Lentiviral Activation Particles (h2) - sc-400431-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 siRNA (h) - sc-36153 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p35 shRNA Plasmid (h) - sc-36153-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p35 shRNA (h) Lentiviral Particles - sc-36153-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CDK5 Activator 1 RNAi - H00008851-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU047541 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0356 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0357 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0358 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN5852 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5852 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11764 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11764

CDK5R1 siRNA (Human) - CRH5844 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CDK5R1 - MBS8232618 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CDK5R1 (NM_003885.2) - SHH260637 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human CDK5R1(NM_003885.2) - SHG164647 from Creative biogene Category siRNA Species Reactivities Human

p35 CRISPR/Cas9 KO Plasmid (h2) - sc-400431-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p35 HDR Plasmid (h2) - sc-400431-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

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