| Gene Symbol |
TYRP1
|
| Entrez Gene |
7306
|
| Alt Symbol |
CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tyrosinase-related protein 1
|
| Other Description |
5,6-dihydroxyindole-2-carboxylic acid oxidase|DHICA oxidase|catalase B|glycoprotein 75|melanoma antigen gp75
|
| Swissprots |
P78468 Q15679 P78469 P17643 Q13721
|
| Accessions |
AAC15468 AAC41924 AAR01256 AAR01257 BAA11759 CAA43288 EAW58709 EAW58710 EAW58711 EAW58712 P17643 AK297887 BAG60208 AL600654 BC052608 AAH52608 CD679533 CR407683 CAG28611 DA278582 X51420 CAA35785 X51455 CAA35820 NM_000550 NP_000541
|
| Function |
Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
|
| Subcellular Location |
Melanosome membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Pigment cells.
|
| Top Pathways |
Melanogenesis, Tyrosine metabolism
|
![Western Blot: TYRP1 Overexpression Lysate (Adult Normal) [NBP2-04163] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TYRP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2404_TYRP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04163-img0001.jpg)