Gene Symbol | TYRP1 |
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Entrez Gene | 7306 |
Alt Symbol | CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN |
Species | Human |
Gene Type | protein-coding |
Description | tyrosinase-related protein 1 |
Other Description | 5,6-dihydroxyindole-2-carboxylic acid oxidase|DHICA oxidase|catalase B|glycoprotein 75|melanoma antigen gp75 |
Swissprots | P78468 Q15679 P78469 P17643 Q13721 |
Accessions | AAC15468 AAC41924 AAR01256 AAR01257 BAA11759 CAA43288 EAW58709 EAW58710 EAW58711 EAW58712 P17643 AK297887 BAG60208 AL600654 BC052608 AAH52608 CD679533 CR407683 CAG28611 DA278582 X51420 CAA35785 X51455 CAA35820 NM_000550 NP_000541 |
Function | Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. |
Subcellular Location | Melanosome membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex (By similarity). {ECO:0000250}. |
Tissue Specificity | Pigment cells. |
Top Pathways | Melanogenesis, Tyrosine metabolism |
Human TRP1 full length protein - ab132102 from Abcam
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Human TRP1 peptide - ab101401 from Abcam
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TYRP1 / gp75 Antibody Blocking Peptide - LS-E5119 from LifeSpan Bioscience
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TYRP1 / gp75 Antibody Blocking Peptide - LS-E16277 from LifeSpan Bioscience
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TYRP1 / gp75 Antibody Blocking Peptide - LS-E16276 from LifeSpan Bioscience
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TYRP1 / gp75 Antibody Blocking Peptide - LS-E16278 from LifeSpan Bioscience
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TYRP1-Antibody-Center-Blocking-Peptide - BP17543c from Abgent, a WuXi AppTec company
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Trp protein - orb80765 from Biorbyt
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Human EDNRBL protein - orb138950 from Biorbyt
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Human TRP1 protein (His Tag) - orb139820 from Biorbyt
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Tyrp1 Blocking Peptide - 33R-1250 from Fitzgerald
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TYRP1 Blocking Peptide - 33R-6659 from Fitzgerald
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TYRP1 Blocking Peptide - 33R-1310 from Fitzgerald
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TYRP1 - H00007306-P01-10 from Acris Antibodies
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TYRP1 - H00007306-P01-25 from Acris Antibodies
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TYRP1 fusion protein - ag10166 from Proteintech Group
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TYRP1 fusion protein - ag10066 from Proteintech Group
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Trp - HOPS-245 from NeoScientific
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Triptorelin Acetate - BP000382-HOR-238 from Syd Labs
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Trp - GWB-610863 from Genway Biotech
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Recombinant Catalase B(katB) - CSB-YP724151FLV CSB-EP724151FLV CSB-BP724151FLV CSB-MP724151FLV from Cusabio
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Recombinant Human 5,6-dihydroxyindole-2-carboxylic acid oxidase(TYRP1) - CSB-YP025399HU CSB-EP025399HU CSB-BP025399HU CSB-MP025399HU from Cusabio
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Recombinant Human TYRP1 Protein - H00007306-P01 from Novus Biologicals
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TYRP1 - TP308595 from Acris Antibodies
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5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1), Recombinant Protein - MBS962981 from MyBioSource
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