| Gene Symbol | ALDH4A1 |
|---|---|
| Entrez Gene | 8659 |
| Alt Symbol | ALDH4, P5CD, P5CDh |
| Species | Human |
| Gene Type | protein-coding |
| Description | aldehyde dehydrogenase 4 family, member A1 |
| Other Description | L-glutamate gamma-semialdehyde dehydrogenase|P5C dehydrogenase|aldehyde dehydrogenase family 4 member A1|delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial|mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase |
| Swissprots | Q16882 A8K1Q7 Q53HU4 Q96IF0 Q9UDI6 Q8IZ38 P30038 D2D4A3 Q5JNV6 B4DGE4 |
| Accessions | EAW94858 EAW94859 EAW94860 P30038 AK222486 BAD96206 AK289972 BAF82661 AK294552 BAG57755 BC007581 AAH07581 BC023600 AAH23600 BM856369 BX649081 DC318624 DQ893505 ABM84431 DQ896489 ABM87488 FJ462711 ACN89883 U24266 AAC50500 U24267 AAC50501 XM_011542352 XP_011540654 XM_011542353 XP_011540655 XR_946786 NM_001161504 NP_001154976 NM_003748 NP_003739 NM_170726 NP_733844 |
| Function | Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. {ECO:0000269|PubMed:22516612}. |
| Subcellular Location | Mitochondrion matrix. |
| Tissue Specificity | Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas. |
| Top Pathways | Arginine and proline metabolism, Alanine, aspartate and glutamate metabolism |