ALDH4A1

Gene Symbol ALDH4A1
Entrez Gene 8659
Alt Symbol ALDH4, P5CD, P5CDh
Species Human
Gene Type protein-coding
Description aldehyde dehydrogenase 4 family, member A1
Other Description L-glutamate gamma-semialdehyde dehydrogenase|P5C dehydrogenase|aldehyde dehydrogenase family 4 member A1|delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial|mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase
Swissprots Q16882 A8K1Q7 Q53HU4 Q96IF0 Q9UDI6 Q8IZ38 P30038 D2D4A3 Q5JNV6 B4DGE4
Accessions EAW94858 EAW94859 EAW94860 P30038 AK222486 BAD96206 AK289972 BAF82661 AK294552 BAG57755 BC007581 AAH07581 BC023600 AAH23600 BM856369 BX649081 DC318624 DQ893505 ABM84431 DQ896489 ABM87488 FJ462711 ACN89883 U24266 AAC50500 U24267 AAC50501 XM_011542352 XP_011540654 XM_011542353 XP_011540655 XR_946786 NM_001161504 NP_001154976 NM_003748 NP_003739 NM_170726 NP_733844
Function Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. {ECO:0000269|PubMed:22516612}.
Subcellular Location Mitochondrion matrix.
Tissue Specificity Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
Top Pathways Arginine and proline metabolism, Alanine, aspartate and glutamate metabolism

ALDH4A1 (C-12) - sc-393354 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALDH4A1 (C-12): sc-393354. Western blot analysis of ALDH4A1 expression in Hep G2 whole cell lysate (A) and human liver (B) and human heart (C) tissue extracts.

ALDH4A1 (E-4) - sc-393339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALDH4A1 (E-4): sc-393339. Western blot analysis of ALDH4A1 expression in human liver tissue extract.

ALDH4A1 (E-11) - sc-398776 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALDH4A1 (E-11): sc-398776. Western blot analysis of ALDH4A1 expression in human liver (A) and human kidney (B) tissue extracts.

ALDH4A1 (F-1) - sc-398911 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALDH4A1 (F-1): sc-398911. Western blot analysis of ALDH4A1 expression in human liver (A), human kidney (B) and human heart (C) tissue extracts and Hep G2 whole cell lysate (D).

ALDH4A1 (H-6) - sc-398894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALDH4A1 (H-6): sc-398894. Western blot analysis of ALDH4A1 expression in human liver (A) and human heart (B) tissue extracts and Hep G2 whole cell lysate (C).

ALDH4A1 (F-25) - sc-130948 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ALDH4A1 (F-25): sc-130948. Western blot analysis of ALDH4A1 expression in human fetal liver tissue extract.

ALDH4A1 (G-18) - sc-69145 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ALDH4A1 (G-18): sc-69145. Western blot analysis of ALDH4A1 expression in non-transfected: sc-117752 (A) and mouse ALDH4A1 transfected: sc-124945 (B) 293T whole cell lysates.

ALDH4A1 (H-300) - sc-367309 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ALDH4A1 (H-300): sc-367309. Western blot analysis of ALDH4A1 expression in NTERA-2 cl.D1 (A) and K-562 (B) whole cell lysates and mouse liver tissue extract (C).

ALDH4A1 (672) - sc-100499 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ALDH4A1 (672): sc-100499. Western blot analysis of ALDH4A1 expression in HeLa whole cell lysate.

Anti-ALDH4A1 antibody - ab196612 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ALDH4A1 antibody (ab196612) at 1/500 dilutionLane 1 : HepG2 cell lysateLane 2 : K562 cell lysateLane 3 : A549 cell lysateLane 4 : BT474 cell lysateLane 5 : mouse skeletal muscle lysateLane 6 : mouse intestine lysateLane 7 : mouse kidney lysate

Anti-ALDH4A1 antibody - ab59011 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ALDH4A1 antibody (ab59011) at 2.5 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-ALDH4A1 antibody - ab167296 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-ALDH4A1 antibody (ab167296) at 1 µg/ml + Human Liver tissue lysate at 50 µgSecondaryGoat anti-Mouse IgG HRP at 1/2500 dilution

Anti-ALDH4A1 antibody - ab80188 from Abcam

Prices $304.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ALDH4A1 antibody (ab80188) at 1/50 dilution + HepG2 cells lysate at 35 µg

Anti-ALDH4A1 antibody [EPR14287] - ab185208 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14287
Anti-ALDH4A1 antibody [EPR14287] (ab185208) at 1/1000 dilution + Human fetal heart at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-ALDH4A1 antibody [EPR14288(B)] - ab181256 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14288(B)
All lanes : Anti-ALDH4A1 antibody [EPR14288(B)] (ab181256) at 1/20000 dilutionLane 1 : Human fetal heart lysateLane 2 : HepG2 cell lysateLane 3 : HeLa cell lysateLane 4 : K562 cell lysateLysates/proteins at 20 µg per lane.Secondarygoat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-ALDH4A1 antibody - C-terminal - ab80180 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ALDH4A1 antibody - C-terminal (ab80180) at 1/50 dilution + HepG2 cell line lysate at 35 µg

Anti-P5CDH / ALDH4A1 Antibody (N-Terminus) - LS-C135183 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ALDH4A1 antibody LS-C135183 Western blot of Rat Kidney lysate. Antibody concentration 1 ug/ml.

Anti-P5CDH / ALDH4A1 Antibody (C-Terminus) - LS-C345759 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of ALDH4A1 Antibody with human Fetal Liver lysate.

Anti-P5CDH / ALDH4A1 Antibody (C-Terminus) - LS-C80756 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ALDH4A1 antibody LS-C80756 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-P5CDH / ALDH4A1 Antibody (aa533-561) - LS-C97487 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ALDH4A1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-P5CDH / ALDH4A1 Antibody (aa522-556) - LS-C344352 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysates from HepG2 cell line and human liver tissue lysate (from left to right) with ALDH4A1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

Anti-P5CDH / ALDH4A1 Antibody (clone 1A12-A5) - LS-C133561 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A12-A5
Immunoperoxidase of monoclonal antibody to ALDH4A1 on formalin-fixed paraffin-embedded human liver tissue.[antibody concentration 5 ug/ml].

Anti-P5CDH / ALDH4A1 Antibody (aa288-314) - LS-C97488 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ALDH4A1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-P5CDH / ALDH4A1 Antibody - LS-C335256 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded mouse lung using ALDH4A1 antibody at dilution of 1:200 (200x lens).

Anti-P5CDH / ALDH4A1 Antibody - LS-C306195 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
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