| Gene Symbol |
RMI1
|
| Entrez Gene |
80010
|
| Alt Symbol |
BLAP75, C9orf76, FAAP75
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RecQ mediated genome instability 1
|
| Other Description |
BLM-associated polypeptide, 75 kDa|BLM-associated protein 75 kDa|RMI1, RecQ mediated genome instability 1, homolog|homolog of yeast RecQ-mediated genome instability 1 (RMI1)|recQ-mediated genome instability protein 1
|
| Swissprots |
Q9H9A7 Q5SQG8 Q05CW3 Q6P1Q4 Q7Z6L6 Q05BX1 Q6PI89 Q5SQG9
|
| Accessions |
EAW62682 EAW62683 Q9H9A7 AJ420435 AK022950 BAB14325 BC020606 AAH20606 BC032494 AAH32494 BC039999 AAH39999 BC044571 BC053549 AAH53549 BC064937 AAH64937 BP327553 DN997105 XM_005252211 XP_005252268 XM_005252213 XP_005252270 XM_011519034 XP_011517336 NM_024945 NP_079221
|
| Function |
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000269|PubMed:15775963, ECO:0000269|PubMed:16537486, ECO:0000269|PubMed:16595695}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15775963}. Note=Forms foci in response to DNA damage.
|
| Top Pathways |
Fanconi anemia pathway
|