| Gene Symbol |
Fadd
|
| Entrez Gene |
14082
|
| Alt Symbol |
Mort1/FADD
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
Fas (TNFRSF6)-associated via death domain
|
| Other Description |
FAS-associated death domain protein|FAS-associating death domain-containing protein|Fas-associating protein with death domain|mediator of receptor induced toxicity|protein FADD
|
| Swissprots |
Q3TC37 Q61082 Q61160
|
| Accessions |
EDL18257 Q61160 AK007648 AK031396 BAC27384 AK084808 BAC39283 AK169798 BAE41374 AK170927 BAE42120 AK179010 AK198513 BC004584 AAH04584 BC021400 AAH21400 U43184 AAA97876 U50406 AAB07789 NM_010175 NP_034305
|
| Function |
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity). {ECO:0000250}.
|
| Top Pathways |
Chagas disease (American trypanosomiasis), TNF signaling pathway, Herpes simplex infection, Tuberculosis, Apoptosis
|