Gene Symbol | Fadd |
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Entrez Gene | 14082 |
Alt Symbol | Mort1/FADD |
Species | Mouse |
Gene Type | protein-coding |
Description | Fas (TNFRSF6)-associated via death domain |
Other Description | FAS-associated death domain protein|FAS-associating death domain-containing protein|Fas-associating protein with death domain|mediator of receptor induced toxicity|protein FADD |
Swissprots | Q3TC37 Q61082 Q61160 |
Accessions | EDL18257 Q61160 AK007648 AK031396 BAC27384 AK084808 BAC39283 AK169798 BAE41374 AK170927 BAE42120 AK179010 AK198513 BC004584 AAH04584 BC021400 AAH21400 U43184 AAA97876 U50406 AAB07789 NM_010175 NP_034305 |
Function | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity). {ECO:0000250}. |
Top Pathways | Chagas disease (American trypanosomiasis), TNF signaling pathway, Herpes simplex infection, Tuberculosis, Apoptosis |
Mouse-Fadd-Antibody-Center-S191-Blocking-Peptide - BP18085c from Abgent, a WuXi AppTec company
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Phospho-mouse-FADDS191-Antibody-Blocking-peptide - BP3103a from Abgent, a WuXi AppTec company
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Phospho-mFADD-pS191-Antibody-Blocking-Peptide - BP3688a from Abgent, a WuXi AppTec company
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Mouse FADD Protein - abx066497 from Abbexa
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Fas Associating Death Domain Containing Protein - 20-9416 from ARP American Research Products
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Recombinant Mouse Protein FADD(Fadd) - CSB-YP730727MO CSB-EP730727MO CSB-BP730727MO CSB-MP730727MO from Cusabio
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Recombinant Mouse FADD Protein - FADD-5430M from Creative Biomart
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Fas Associating Death Domain Containing Protein (FADD), Recombinant Protein - MBS2009820 from MyBioSource
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FADD Recombinant Protein (OPCD00653) - OPCD00653 from Aviva Systems Biology
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FADD Recombinant Protein (OPCD03060) - OPCD03060 from Aviva Systems Biology
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Protein FADD (Fadd), Recombinant Protein - MBS1388724 from MyBioSource
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