Gene Symbol | Fadd |
---|---|
Entrez Gene | 14082 |
Alt Symbol | Mort1/FADD |
Species | Mouse |
Gene Type | protein-coding |
Description | Fas (TNFRSF6)-associated via death domain |
Other Description | FAS-associated death domain protein|FAS-associating death domain-containing protein|Fas-associating protein with death domain|mediator of receptor induced toxicity|protein FADD |
Swissprots | Q3TC37 Q61082 Q61160 |
Accessions | EDL18257 Q61160 AK007648 AK031396 BAC27384 AK084808 BAC39283 AK169798 BAE41374 AK170927 BAE42120 AK179010 AK198513 BC004584 AAH04584 BC021400 AAH21400 U43184 AAA97876 U50406 AAB07789 NM_010175 NP_034305 |
Function | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity). {ECO:0000250}. |
Top Pathways | Chagas disease (American trypanosomiasis), TNF signaling pathway, Herpes simplex infection, Tuberculosis, Apoptosis |
FADD CRISPR/Cas9 KO Plasmid (m) - sc-420279 from Santa Cruz Biotechnology
|
||||||||
FADD HDR Plasmid (m) - sc-420279-HDR from Santa Cruz Biotechnology
|
||||||||
FADD Double Nickase Plasmid (m) - sc-420279-NIC from Santa Cruz Biotechnology
|
||||||||
FADD Double Nickase Plasmid (m2) - sc-420279-NIC-2 from Santa Cruz Biotechnology
|
||||||||
FADD CRISPR Activation Plasmid (m) - sc-420279-ACT from Santa Cruz Biotechnology
|
||||||||
FADD CRISPR Activation Plasmid (m2) - sc-420279-ACT-2 from Santa Cruz Biotechnology
|
||||||||
FADD Lentiviral Activation Particles (m) - sc-420279-LAC from Santa Cruz Biotechnology
|
||||||||
FADD Lentiviral Activation Particles (m2) - sc-420279-LAC-2 from Santa Cruz Biotechnology
|
||||||||
FADD siRNA (m) - sc-35351 from Santa Cruz Biotechnology
|
||||||||
FADD shRNA Plasmid (m) - sc-35351-SH from Santa Cruz Biotechnology
|
||||||||
FADD shRNA (m) Lentiviral Particles - sc-35351-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU026091 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN30898 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30898 from Sigma-Aldrich
|
||||||||
FADD siRNA (Mouse) - CRM1300 from Cohesion Biosciences
|
||||||||
FADD - MBS8239009 from MyBioSource
|
||||||||
shRNA set against Mouse FADD (NM_010175.5) - SHH288701 from Creative biogene
|
||||||||
shRNA set against Mouse Fadd(NM_010175.5) - SHH044345 from Creative biogene
|
||||||||
Mouse FADD siRNA - orb280776 from Biorbyt
|
||||||||
FADD shRNA Plasmid (Mouse) - CHM1300 from Cohesion Biosciences
|
||||||||
FADD miRNA 3'UTR clone - MiUTR1M-04561 from Creative biogene
|