COPS4
| Gene Symbol | COPS4 |
|---|---|
| Entrez Gene | 51138 |
| Alt Symbol | CSN4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | COP9 signalosome subunit 4 |
| Other Description | COP9 constitutive photomorphogenic homolog subunit 4|COP9 signalosome complex subunit 4|JAB1-containing signalosome subunit 4|SGN4|signalosome subunit 4 |
| Swissprots | Q561W7 B3KST5 Q9BT78 Q9Y677 Q9NW31 B3KN88 |
| Accessions | EAX05921 EAX05922 Q9BT78 AF100757 AAD43021 AK001148 BAG50860 AK001210 BAA91555 AK024005 BAG51250 AK094238 BAG52847 AK223178 BAD96898 BC004302 AAH04302 BC009292 AAH09292 BC093007 AAH93007 CD690475 JF432698 ADZ15915 XM_011532019 XP_011530321 NM_001258006 NP_001244935 NM_016129 NP_057213 |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
| Subcellular Location | Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. |
COPS4 293 Cell Lysate - 402194 from ABBIOTEC
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COPS4 Overexpression Lysate (Native) - NBL1-09382 from Novus Biologicals
![Western Blot: COPS4 Overexpression Lysate (Adult Normal) [NBL1-09382] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for COPS4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3381_COPS4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09382-img0002.jpg)
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COPS4 Over-expression Lysate Product - GWB-DBBF18 from Genway Biotech
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Panoply™ Human COPS4 Knockdown Stable Cell Line - CSC-DC003501 from Creative biogene
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