COPS4

Gene Symbol COPS4
Entrez Gene 51138
Alt Symbol CSN4
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 4
Other Description COP9 constitutive photomorphogenic homolog subunit 4|COP9 signalosome complex subunit 4|JAB1-containing signalosome subunit 4|SGN4|signalosome subunit 4
Swissprots Q561W7 B3KST5 Q9BT78 Q9Y677 Q9NW31 B3KN88
Accessions EAX05921 EAX05922 Q9BT78 AF100757 AAD43021 AK001148 BAG50860 AK001210 BAA91555 AK024005 BAG51250 AK094238 BAG52847 AK223178 BAD96898 BC004302 AAH04302 BC009292 AAH09292 BC093007 AAH93007 CD690475 JF432698 ADZ15915 XM_011532019 XP_011530321 NM_001258006 NP_001244935 NM_016129 NP_057213
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.
Subcellular Location Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

CSN4 CRISPR/Cas9 KO Plasmid (h) - sc-412126 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN4 HDR Plasmid (h) - sc-412126-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN4 Double Nickase Plasmid (h) - sc-412126-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN4 Double Nickase Plasmid (h2) - sc-412126-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN4 CRISPR Activation Plasmid (h) - sc-412126-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN4 CRISPR Activation Plasmid (h2) - sc-412126-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN4 Lentiviral Activation Particles (h) - sc-412126-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN4 Lentiviral Activation Particles (h2) - sc-412126-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN4 siRNA (h) - sc-60459 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN4 shRNA Plasmid (h) - sc-60459-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN4 shRNA (h) Lentiviral Particles - sc-60459-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU029321 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6434 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6434 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03587 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03587

COPS4 siRNA (Human) - CRH9556 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS4 - MBS8230550 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COPS4(NM_016129.2) - SHG192655 from Creative biogene

Category siRNA
Species Reactivities Human

Human COPS4 siRNA - orb270058 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS4 shRNA Plasmid (Human) - CHH9556 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COPS4 miRNA 3'UTR clone - MiUTR1H-02358 from Creative biogene

Species Reactivities Human
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